Testing for gene-environment and gene-gene interactions under monotonicity constraints

DOI10.1080/01621459.2012.726892MaRDI QIDQ4904722zbMATH OpenOpenAlexFDO

Authors Summer S. Han, Philip S. Rosenberg, Nilanjan Chatterjee

Publication date 31 January 2013

Published in Journal of the American Statistical Association (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1080/01621459.2012.726892

zbMATH Keywords

isotonic regressionorder restrictionsgene-environment interactionsgenome-wide association study (GWAS)constrained likelihood ratio test

Mathematics Subject Classification ID

Parametric hypothesis testing (62F03) Applications of statistics to biology and medical sciences; meta analysis (62P10) Genetics and epigenetics (92D10) Parametric inference under constraints (62F30)

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Cites work

• scientific article; zbMATH DE number 193111 (Why is no real title available?)
• scientific article; zbMATH DE number 3390139 (Why is no real title available?)
• A TEST OF HOMOGENEITY FOR ORDERED ALTERNATIVES
• A TEST OF HOMOGENEITY FOR ORDERED ALTERNATIVES. II
• An algorithm for isotonic regression for two or more independent variables
• An algorithm for monotone regression with one or more independent variables
• Logistic disease incidence models and case-control studies
• Semiparametric maximum likelihood estimation exploiting gene-environment independence in case-control studies

Cited in

(10)

• An exposure-weighted score test for genetic associations integrating environmental risk factors
• Detecting two-locus gene-gene effects using monotonisation of the penetrance matrix
• Powerful tests for detecting a gene effect in the presence of possible gene-gene interactions using garrote kernel machines
• A unified set-based test with adaptive filtering for gene-environment interaction analyses
• Algebraic methods for studying interactions between epidemiological variables
• Detecting rare and common haplotype-environment interaction under uncertainty of gene-environment independence assumption
• Two-stage testing procedures with independent filtering for genome-wide gene-environment interaction
• AGGrEGATOr: A Gene-based GEne-Gene interActTiOn test for case-control association studies
• Testing for gene-gene interaction in case-control GWAS
• Testing for gene-environment interaction under exposure misspecification

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