Blinded and unblinded sample size reestimation in crossover trials balanced for period

DOI10.1002/bimj.201700092zbMath1405.62017arXiv1803.10130OpenAlexW2964170127WikidataQ58800760 ScholiaQ58800760MaRDI QIDQ4962948

Michael J. Grayling, Adrian P. Mander, James M. S. Wason

Publication date: 5 November 2018

Published in: Biometrical Journal (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1803.10130

zbMATH Keywords

crossover trialinternal pilot studysample size reestimationblinded sample size

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sampling theory, sample surveys (62D05)

Uses Software

• mclust
• R
• kml3d

Cites Work

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• Optimal cross-over designs for full interaction models
• Enhanced model-based clustering, density estimation, and discriminant analysis software:\newline MCLUST
• Blinded sample size recalculation in multicentre trials with normally distributed outcome
• Sample-Size Redetermination for Repeated Measures Studies
• A Multiple Comparison Procedure for Comparing Several Treatments with a Control
• Sample size re-estimation without unblinding for normally distributed outcomes with unknown variance
• A Two-Sample Test for a Linear Hypothesis Whose Power is Independent of the Variance

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