A radial basis function (RBF) finite difference method for the simulation of reaction-diffusion equations on stationary platelets within the augmented forcing method

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Publication:4964982

DOI10.1002/FLD.3880zbMATH Open1455.65136arXiv1310.5207OpenAlexW3123416467MaRDI QIDQ4964982FDOQ4964982


Authors: Varun Shankar, Grady B. Wright, A. L. Fogelson, Robert M. Kirby Edit this on Wikidata


Publication date: 5 March 2021

Published in: International Journal for Numerical Methods in Fluids (Search for Journal in Brave)

Abstract: We present a computational method for solving the coupled problem of chemical transport in a fluid (blood) with binding/unbinding of the chemical to/from cellular (platelet) surfaces in contact with the fluid, and with transport of the chemical on the cellular surfaces. The overall framework is the Augmented Forcing Point Method (AFM) (emph{L. Yao and A.L. Fogelson, Simulations of chemical transport and reaction in a suspension of cells I: An augmented forcing point method for the stationary case, IJNMF (2012) 69, 1736-52.}) for solving fluid-phase transport in a region outside of a collection of cells suspended in the fluid. We introduce a novel Radial Basis Function-Finite Difference (RBF-FD) method to solve reaction-diffusion equations on the surface of each of a collection of 2D stationary platelets suspended in blood. Parametric RBFs are used to represent the geometry of the platelets and give accurate geometric information needed for the RBF-FD method. Symmetric Hermite-RBF interpolants are used for enforcing the boundary conditions on the fluid-phase chemical concentration, and their use removes a significant limitation of the original AFM. The efficacy of the new methods are shown through a series of numerical experiments; in particular, second order convergence for the coupled problem is demonstrated.


Full work available at URL: https://arxiv.org/abs/1310.5207




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