Robustness analysis of spatiotemporal models in the presence of extrinsic fluctuations

DOI10.1137/15M1052317zbMATH Open1386.35204arXiv1610.01323OpenAlexW2529175896MaRDI QIDQ4977149FDOQ4977149

Authors: Andreas Hellander, Jan Klosa, S. MacNamara, Per Lötstedt 

Publication date: 3 August 2017

Published in: SIAM Journal on Applied Mathematics (Search for Journal in Brave)

Abstract: We analyze the governing partial differential equations of a model of pole-to-pole oscillations of the MinD protein in a bacterial cell. The sensitivity to extrinsic noise in the parameters of the model is explored. Our analysis shows that overall, the oscillations are robust to extrinsic perturbations in the sense that small perturbations in reaction coefficients result in small differences in the frequency and in the amplitude. However, a combination of analysis and simulation also reveals that the oscillations are more sensitive to some extrinsic time-scales than to others.

Full work available at URL: https://arxiv.org/abs/1610.01323

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zbMATH Keywords

robustnesslinear stabilityperturbation analysisextrinsic noise

Mathematics Subject Classification ID

Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) PDEs with randomness, stochastic partial differential equations (35R60) Classical flows, reactions, etc. in chemistry (92E20)

Cites Work

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Cited In (5)

• A model of oscillatory protein dynamics in bacteria
• Positivity-preserving methods for ordinary differential equations
• Title not available (Why is that?)
• Applications of Magnus expansions and pseudospectra to Markov processes
• Localization and pseudospectra of twisted Toeplitz matrices with applications to ion channels

Uses Software

• URDME

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