Entrainment dynamics of forced hierarchical circadian systems revealed by 2-dimensional maps

DOI10.1137/19M1307676MaRDI QIDQ4983501zbMATH OpenOpenAlexWikidataFDO

Authors Guangyuan Liao, Casey O. Diekman, Amitabha Bose

Publication date 20 April 2021

Published in SIAM Journal on Applied Dynamical Systems (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1912.07121

zbMATH Keywords

limit cyclecircadian rhythmcoupled oscillatorsPoincaré map

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) Nonlinear oscillations and coupled oscillators for ordinary differential equations (34C15) Biological rhythms and synchronization (92B25)

Abstract: The ability of a circadian system to entrain to the 24-hour light-dark cycle is one of its most important properties. A new tool, called the entrainment map, was recently introduced to study this process for a single oscillator. Here we generalize the map to study the effects of light-dark forcing in a hierarchical system consisting of a central circadian oscillator that drives a peripheral circadian oscillator. We develop techniques to reduced the higher dimensional phase space of the coupled system to derive a generalized 2-D entrainment map. Determining the nature of various fixed points, together with an understanding of their stable and unstable manifolds, leads to conditions for existence and stability of periodic orbits of the circadian system. We use the map to investigate how various properties of solutions depend on parameters and initial conditions including the time to and direction of entrainment. We show that the concepts of phase advance and phase delay need to be carefully assessed when considering hierarchical systems.

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Cited in

(5)

• Entrainment versus chaos in a model for a circadian oscillator driven by light-dark cycles
• A two-step model of human entrainment: a quantitative study of circadian period and phase of entrainment
• Return map structure and entrainment in a time-state-scale re-entrant system
• Dynamic entrainment: a deep learning and data-driven process approach for synchronization in the Hodgkin-Huxley model
• Entrainment within hierarchical circadian oscillator networks

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