Directional search-and-capture model of cytoneme-based morphogenesis

DOI10.1137/20M1339891MaRDI QIDQ4990943zbMATH OpenOpenAlexWikidataFDO

Authors Paul C. Bressloff

Publication date 2 June 2021

Published in SIAM Journal on Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2009.06095

zbMATH Keywords

cytonemesmorphogenesissearch processesstochastic resetting

Mathematics Subject Classification ID

Applications of Markov renewal processes (reliability, queueing networks, etc.) (60K20) Developmental biology, pattern formation (92C15) Cell biology (92C37)

Abstract: In this paper we develop a directional search-and-capture model of cytoneme-based morphogenesis. We consider a single cytoneme nucleating from a source cell and searching for a set of $N$ target cells $Omeg{a}_{k}subset{R}^d$, $k=1,ldots,N$, with $dgeq2$. We assume that each time the cytoneme nucleates, it grows in a random direction so that the probability of being oriented towards the $k$-th target is $p_k$ with $su{m}_{k=1}^N{p}_k<1$. Hence, there is a non-zero probability of failure to find a target unless there is some mechanism for returning to the nucleation site and subsequently nucleating in a new direction. We model the latter as a one-dimensional search process with stochastic resetting, finite returns times and refractory periods. We use a renewal method to calculate the splitting probabilities and conditional mean first passage times (MFPTs) for the cytoneme to be captured by a given target cell. We then determine the steady-state accumulation of morphogen over the set of target cells following multiple rounds of search-and-capture events and morphogen degradation. This then yields the corresponding morphogen gradient across the set of target cells, whose steepness depends on the resetting rate. We illustrate the theory by considering a single layer of target cells, and discuss the extension to multiple cytonemes.

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Cites work

• A first-passage-time theory for search and capture of chromosomes by microtubules in mitosis
• A Proof for the Queuing Formula: L = λW
• Diffusion with optimal resetting
• Diffusion with resetting in arbitrary spatial dimension
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• Directed intermittent search with stochastic resetting
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• scientific article; zbMATH DE number 3174015 (Why is no real title available?)
• Modeling active cellular transport as a directed search process with stochastic resetting and delays
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Cited in

(2)

• Direct vs. Synaptic Coupling in a Mathematical Model of Cytoneme-Based Morphogen Gradient Formation
• Modeling active cellular transport as a directed search process with stochastic resetting and delays

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