Global Hopf bifurcation in the ZIP regulatory system

DOI10.1007/S00285-014-0836-1zbMATH Open1371.34066arXiv1401.5597OpenAlexW2013660942WikidataQ51025657 ScholiaQ51025657MaRDI QIDQ500337FDOQ500337

Authors: Juliane Claus, Mariya Ptashnyk, Ansgar Bohmann, Andrés Chavarría-Krauser 

Publication date: 2 October 2015

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: Regulation of zinc uptake in roots of Arabidopsis thaliana has recently been modeled by a system of ordinary differential equations based on the uptake of zinc, expression of a transporter protein and the interaction between an activator and inhibitor. For certain parameter choices the steady state of this model becomes unstable upon variation in the external zinc concentration. Numerical results show periodic orbits emerging between two critical values of the external zinc concentration. Here we show the existence of a global Hopf bifurcation with a continuous family of stable periodic orbits between two Hopf bifurcation points. The stability of the orbits in a neighborhood of the bifurcation points is analyzed by deriving the normal form, while the stability of the orbits in the global continuation is shown by calculation of the Floquet multipliers. From a biological point of view, stable periodic orbits lead to potentially toxic zinc peaks in plant cells. Buffering is believed to be an efficient way to deal with strong transient variations in zinc supply. We extend the model by a buffer reaction and analyze the stability of the steady state in dependence of the properties of this reaction. We find that a large enough equilibrium constant of the buffering reaction stabilizes the steady state and prevents the development of oscillations. Hence, our results suggest that buffering has a key role in the dynamics of zinc homeostasis in plant cells.

Full work available at URL: https://arxiv.org/abs/1401.5597

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zbMATH Keywords

stabilityHopf bifurcationperiodic orbitstransport processes in plantszinc uptake

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Topological structure of integral curves, singular points, limit cycles of ordinary differential equations (34C05) Bifurcation theory for ordinary differential equations (34C23) Stability of solutions to ordinary differential equations (34D20) Bifurcations of limit cycles and periodic orbits in dynamical systems (37G15) Plant biology (92C80)

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Cited In (3)

• Instability of oscillations in the Rosenzweig-MacArthur model of one consumer and two resources
• Homeostasis patterns
• Dynamical analysis of the glucose zymolysis model

Uses Software

• psSchur

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