Type III responses to transient inputs in hybrid nonlinear neuron models

DOI10.1137/20M1354970MaRDI QIDQ5004529zbMATH OpenOpenAlexFDO

Authors Justyna Signerska-Rynkowska, Jonathan D. Touboul, Jonathan Rubin

Publication date 2 August 2021

Published in SIAM Journal on Applied Dynamical Systems (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2007.11968

zbMATH Keywords

hybrid dynamical systemspost-inhibitory facilitationslope detectiontransient responsestype III excitability

Mathematics Subject Classification ID

Hybrid systems of ordinary differential equations (34A38) Qualitative investigation and simulation of ordinary differential equation models (34C60) Topological dynamics of nonautonomous systems (37B55) Orbit growth in dynamical systems (37C35) Dynamical systems in biology (37N25) Neural networks for/in biological studies, artificial life and related topics (92B20)

Abstract: Experimental characterization of neuronal dynamics involves recording both of spontaneous activity patterns and of responses to transient and sustained inputs. While much theoretical attention has been devoted to the spontaneous activity of neurons, less is known about the dynamic mechanisms shaping their responses to transient inputs, although these bear significant physiological relevance. Here, we study responses to transient inputs in a widely used class of neuron models (nonlinear adaptive hybrid models) well-known to reproduce a number of biologically realistic behaviors. We focus on responses to transient inputs that have been previously associated with Type III neurons, arguably the least studied category in Hodgkin's classification, which are those neurons that never exhibit continuous firing in response to sustained excitatory currents. The two phenomena that we study are post-inhibitory facilitation, in which an otherwise subthreshold excitatory input can induce a spike if it is applied with proper timing after an inhibitory pulse, and slope detection, in which a neuron spikes to a transient input only when the input's rate of change is in a specific, bounded range. We analyze the origin of these phenomena in nonlinear hybrid models and provide a geometric characterization of dynamical structures associated with PIF in the system and an analytical study of slope detection for tent inputs. While the necessary and sufficient conditions for these behaviors are easily satisfied in neurons with Type III excitability, our proofs are quite general and valid for neurons that do not exhibit Type III excitability as well. This study therefore provides a framework for the mathematical analysis of these responses to transient inputs associated with Type III neurons in other systems and for advancing our understanding of these systems' computational properties.

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Cited in

(3)

• Type III excitability, slope sensitivity and coincidence detection
• Activity patterns of a two-timescale neuronal ring model with voltage-dependent, piecewise smooth inhibitory coupling
• Rate-induced tipping: thresholds, edge states and connecting orbits

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