Localised signalling compartments in 2D coupled by a bulk diffusion field: quorum sensing and synchronous oscillations in the well-mixed limit

DOI10.1017/S0956792520000261zbMATH Open1479.35051arXiv2006.03775MaRDI QIDQ5014476FDOQ5014476

Authors: Sarafa A. Iyaniwura, Michael J. Ward 

Publication date: 8 December 2021

Published in: European Journal of Applied Mathematics (Search for Journal in Brave)

Abstract: We analyze oscillatory instabilities for a coupled PDE-ODE system modeling the communication between localized spatially segregated dynamically active signaling compartments that are coupled through a passive extracellular bulk diffusion field in a bounded 2-D domain. Each signaling compartment is assumed to secrete a chemical into the extracellular medium (bulk region) and it can also sense the concentration of this chemical in the region around its boundary. This feedback from the bulk region, resulting from the entire collection of cells, in turn modifies the intracellular dynamics within each cell. In the limit where the signaling compartments are circular disks with a small common radius $epsilonll1$ and where the bulk diffusivity is asymptotically large, a matched asymptotic analysis is used to reduce the dimensionless PDE-ODE system into a nonlinear ODE system with global coupling. For Sel'kov reaction kinetics, this ODE system for the intracellular dynamics and the spatial average of the bulk diffusion field is then used to investigate oscillatory instabilities in the dynamics of the cells that are triggered due to the global coupling. In particular, numerical bifurcation software on the ODEs is used to study the overall effect of coupling defective cells (cells that behave differently from the remaining cells) to a group of identical cells. Moreover, when the number of cells is large, the Kuramoto order parameter is computed to predict the degree of phase synchronization of the intracellular dynamics. Quorum sensing behavior, characterized by the onset of collective behavior in the intracellular dynamics as the number of cells increases above a threshold, is also studied. Our analysis shows that the cell population density plays a dual role of triggering and then quenching synchronous oscillations in the intracellular dynamics.

Full work available at URL: https://arxiv.org/abs/2006.03775

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zbMATH Keywords

Hopf bifurcationquorum sensingsynchronous oscillationsPDE-ODE systemglobal couplingKuramoto order parameterbulk diffusiondefector cells

Mathematics Subject Classification ID

Singular perturbations in context of PDEs (35B25) Bifurcations in context of PDEs (35B32) Pattern formations in context of PDEs (35B36) Initial-boundary value problems for second-order parabolic equations (35K20) Biological rhythms and synchronization (92B25)

Cites Work

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• Individual-based model for quorum sensing with background flow
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Cited In (4)

• Traveling waves in response to a diffusing quorum sensing signal in spatially-extended bacterial colonies
• Approximating the dynamics of communicating cells in a diffusive medium by ODEs -- homogenization with localization
• Cellular diffusion processes in singularly perturbed domains
• Dynamical quorum-sensing in oscillators coupled through an external medium

Uses Software

• Matlab
• XPPAUT
• ode23
• ode45
• Ode15s
• ode113
• ode23s
• MATLAB ODE suite

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