Asymptotic limits for a nonlinear integro-differential equation modelling leukocytes' rolling on arterial walls

DOI10.1088/1361-6544/AC3EB5MaRDI QIDQ5019958zbMATH OpenOpenAlexWikidataFDO

Authors Vuk Milišić, Christian Schmeiser

Publication date 11 January 2022

Published in Nonlinearity (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2011.06965

zbMATH Keywords

asymptotic analysisdelayed gradient flowleukocyte rollingLipschitz mechanical energyVolterra integral equations

Mathematics Subject Classification ID

Volterra integral equations (45D05) Asymptotics of solutions to integral equations (45M05) General biology and biomathematics (92B05) Cell movement (chemotaxis, etc.) (92C17) Physiological flow (92C35)

Abstract: We consider a non-linear integro-differential model describing $z$, the position of the cell center on the real line presented in [Grec et al., J. Theo. Bio. 2018]. We introduce a new $varepsilon$-scaling and we prove rigorously the asymptotics when $varepsilon$ goes to zero. We show that this scaling characterizes the long-time behavior of the solutions of our problem in the cinematic regime (the velocity $dotz$ tends to a limit). The convergence results are first given when $psi$, the elastic energy associated to linkages, is convex and regular (the second order derivative of $psi$ is bounded). In the absence of blood flow, when $psi$, is quadratic, we compute the final position $z_{i}nfty$ to which we prove that $z$ tends. We then build a rigorous mathematical framework for $psi$ being convex but only Lipschitz. We extend convergence results with respect to $varepsilon$ to this case when $ps{i}^{\prime }$ admits a finite number of jumps. In the last part, we show that in the constant force case (see Model 3 in [Grec et al], $psi$ is the absolute value), we solve explicitly the problem and recover the above asymptotic results.

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Cited in

(1)

• An integro-differential equation arising as a limit of individual cell-based models

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