Bias-corrected methods for estimating the receiver operating characteristic surface of continuous diagnostic tests

DOI10.1214/16-EJS1202MaRDI QIDQ502787zbMATH OpenOpenAlexFDO

Authors Khan To Duc, Monica Chiogna, Gianfranco Adimari

Publication date 11 January 2017

Published in Electronic Journal of Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1510.03225, https://projecteuclid.org/euclid.ejs/1478747030

zbMATH Keywords

diagnostic testsmissing at randomMonte Carlo simulationdisease statusreceiver operating characteristic (ROC) surface analysistrue class fractionsverification bias

Mathematics Subject Classification ID

Nonparametric hypothesis testing (62G10) Asymptotic properties of nonparametric inference (62G20) Applications of statistics to biology and medical sciences; meta analysis (62P10) Empirical decision procedures; empirical Bayes procedures (62C12)

Abstract: Verification bias is a well-known problem that may occur in the evaluation of predictive ability of diagnostic tests. When a binary disease status is considered, various solutions can be found in the literature to correct inference based on usual measures of test accuracy, such as the receiver operating characteristic (ROC) curve or the area underneath. Evaluation of the predictive ability of continuous diagnostic tests in the presence of verification bias for a three-class disease status is here discussed. In particular, several verification bias-corrected estimators of the ROC surface and of the volume underneath are proposed. Consistency and asymptotic normality of the proposed estimators are established and their finite sample behavior is investigated by means of Monte Carlo simulation studies. Two illustrations are also given.

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• Inverse probability weighting estimation of the volume under the ROC surface in the presence of verification bias
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• ROC Curve Estimation When Covariates Affect the Verification Process
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