Existence of weak solutions to multiphase Cahn-Hilliard-Darcy and Cahn-Hilliard-Brinkman models for stratified tumor growth with chemotaxis and general source terms
From MaRDI portal
Publication:5037294
DOI10.1080/03605302.2021.1966803zbMATH Open1484.35148arXiv2105.09068OpenAlexW3198397443MaRDI QIDQ5037294FDOQ5037294
Authors: Patrik Knopf, Andrea Signori 
Publication date: 28 February 2022
Published in: Communications in Partial Differential Equations (Search for Journal in Brave)
Abstract: We investigate a multiphase Cahn-Hilliard model for tumor growth with general source terms. The multiphase approach allows us to consider multiple cell types and multiple chemical species (oxygen and/or nutrients) that are consumed by the tumor. Compared to classical two-phase tumor growth models, the multiphase model can be used to describe a stratified tumor exhibiting several layers of tissue (e.g., proliferating, quiescent and necrotic tissue) more precisely. Our model consists of a convective Cahn-Hilliard type equation to describe the tumor evolution, a velocity equation for the associated volume-averaged velocity field, and a convective reaction-diffusion type equation to describe the density of the chemical species. The velocity equation is either represented by Darcy's law or by the Brinkman equation. We first construct a global weak solution of the multiphase Cahn-Hilliard-Brinkman model. After that, we show that such weak solutions of the system converge to a weak solution of the multiphase Cahn-Hilliard-Darcy system as the viscosities tend to zero in some suitable sense. This means that the existence of a global weak solution to the Cahn-Hilliard-Darcy system is also established.
Full work available at URL: https://arxiv.org/abs/2105.09068
Recommendations
- Global weak solutions and asymptotic limits of a Cahn-Hilliard-Darcy system modelling tumour growth
- On a Cahn-Hilliard-Darcy system for tumour growth with solution dependent source terms
- Cahn–Hilliard–Brinkman model for tumor growth with possibly singular potentials
- Analysis of a Cahn-Hilliard-Brinkman model for tumour growth with chemotaxis
- Weak and stationary solutions to a Cahn-Hilliard-Brinkman model with singular potentials and source terms
Darcy's lawtumor growthmultiphase modelconvective Cahn-Hilliard equationBrinkman's lawlimit of vanishing viscosities
Medical applications (general) (92C50) Weak solutions to PDEs (35D30) Initial-boundary value problems for higher-order parabolic equations (35K35) Unilateral problems for nonlinear parabolic equations and variational inequalities with nonlinear parabolic operators (35K86) Stokes and related (Oseen, etc.) flows (76D07) Cell movement (chemotaxis, etc.) (92C17)
Cites Work
- Mathematical tools for the study of the incompressible Navier-Stokes equations and related models
- Title not available (Why is that?)
- Title not available (Why is that?)
- A history of the study of solid tumour growth: the contribution of mathematical modelling
- On a Cahn-Hilliard type phase field system related to tumor growth
- An Introduction to the Mathematical Theory of the Navier-Stokes Equations
- General diffuse-interface theories and an approach to predictive tumor growth modeling
- Title not available (Why is that?)
- Avascular growth, angiogenesis and vascular growth in solid tumours: The mathematical modelling of the stages of tumour development
- Nonlinear simulation of tumor necrosis, neo-vascularization and tissue invasion via an adaptive finite-element/level-set method
- Mathematical Models of Avascular Tumor Growth
- A two-phase model of solid tumour growth
- Modelling solid tumour growth using the theory of mixtures
- Linear functional analysis. An application-oriented introduction. Translated from the 6th German edition by Robert Nürnberg
- Free boundary problems for systems of Stokes equations
- Free Boundary Problems Associated with Multiscale Tumor Models
- Interactions between a uniformly proliferating tumour and its surroundings: uniform material properties
- Analysis of a Darcy--Cahn--Hilliard diffuse interface model for the Hele-Shaw flow and its fully discrete finite element approximation
- Three-dimensional multispecies nonlinear tumor growth. II: Tumor invasion and angiogenesis
- Three-dimensional multispecies nonlinear tumor growth. I: Model and numerical method
- Free boundary value problems associated with the growth and development of multicellular spheroids
- On Stokes operators with variable viscosity in bounded and unbounded domains
- A new mathematical model for avascular tumour growth
- On a diffuse interface model of tumour growth
- Analysis of a diffuse interface model of multispecies tumor growth
- Asymptotic analyses and error estimates for a Cahn-Hilliard type phase field system modelling tumor growth
- Formal asymptotic limit of a diffuse-interface tumor-growth model
- Vanishing viscosities and error estimate for a Cahn-Hilliard type phase field system related to tumor growth
- On a Cahn-Hilliard-Darcy system for tumour growth with solution dependent source terms
- Global weak solutions and asymptotic limits of a Cahn-Hilliard-Darcy system modelling tumour growth
- A Cahn-Hilliard-Darcy model for tumour growth with chemotaxis and active transport
- Well-posedness of a Cahn-Hilliard system modelling tumour growth with chemotaxis and active transport
- On the Cahn-Hilliard-Brinkman system
- Interactions between a uniformly proliferating tumour and its surroundings: stability analysis for variable material properties
- Selected topics in cancer modeling. Genesis, evolution, immune competition, and therapy
- On a diffuse interface model for tumour growth with non-local interactions and degenerate mobilities
- Incompressible limit of a mechanical model of tumour growth with viscosity
- A Hele-Shaw-Cahn-Hilliard model for incompressible two-phase flows with different densities
- Optimal control of treatment time in a diffuse interface model of tumor growth
- A multiphase Cahn-Hilliard-Darcy model for tumour growth with necrosis
- Optimal distributed control of a diffuse interface model of tumor growth
- The Cahn-Hilliard-Hele-Shaw system with singular potential
- Optimal treatment for a phase field system of Cahn-Hilliard type modeling tumor growth by asymptotic scheme
- Optimal distributed control of an extended model of tumor growth with logarithmic potential
- Well-posedness for the Brinkman-Cahn-Hilliard system with unmatched viscosities
- On a nonlinear model for tumour growth with drug application
- Analysis of a Cahn-Hilliard-Brinkman model for tumour growth with chemotaxis
- Long-time dynamics and optimal control of a diffuse interface model for tumor growth
- Optimal control theory and advanced optimality conditions for a diffuse interface model of tumor growth
- On a multi-species Cahn-Hilliard-Darcy tumor growth model with singular potentials
- Optimality conditions for an extended tumor growth model with double obstacle potential via deep quench approach
- Optimal medication for tumors modeled by a Cahn-Hilliard-Brinkman equation
- Vanishing parameter for an optimal control problem modeling tumor growth
- On a Cahn-Hilliard-Brinkman model for tumor growth and its singular limits
- Weak and stationary solutions to a Cahn-Hilliard-Brinkman model with singular potentials and source terms
- Cahn-Hilliard-Brinkman systems for tumour growth
- On a phase field model of Cahn-Hilliard type for tumour growth with mechanical effects
- Analysis of a new multispecies tumor growth model coupling 3D phase-fields with a 1D vascular network
- Second-order analysis of an optimal control problem in a phase field tumor growth model with singular potentials and chemotaxis
- On a class of non-local phase-field models for tumor growth with possibly singular potentials, chemotaxis, and active transport
- Sparse Optimal Control of a Phase Field Tumor Model with Mechanical Effects
- Sparse optimal control of a phase field system with singular potentials arising in the modeling of tumor growth
- Learning patient-specific parameters for a diffuse interface glioblastoma model from neuroimaging data
- Parameter identification for nonlocal phase field models for tumor growth via optimal control and asymptotic analysis
- Nonlocal Cahn-Hilliard-Brinkman system with regular potential: regularity and optimal control
- Strong well-posedness and inverse identification problem of a non-local phase field tumour model with degenerate mobilities
Cited In (18)
- Optimal distributed control for a Cahn-Hilliard type phase field system related to tumor growth
- On a Cahn-Hilliard-Keller-Segel model with generalized logistic source describing tumor growth
- Analysis of a Cahn-Hilliard-Brinkman model for tumour growth with chemotaxis
- Optimal distributed control for a Cahn-Hilliard-Darcy system with mass sources, unmatched viscosities and singular potential
- On a Cahn-Hilliard-Darcy system for tumour growth with solution dependent source terms
- Global weak solutions and asymptotic limits of a Cahn-Hilliard-Darcy system modelling tumour growth
- On a Phase Field Model for RNA-Protein Dynamics
- Nutrient control for a viscous Cahn-Hilliard-Keller-Segel model with logistic source describing tumor growth
- Well-posedness and optimal control for a viscous Cahn-Hilliard-Oono system with dynamic boundary conditions
- Two-phase flows through porous media described by a Cahn-Hilliard-Brinkman model with dynamic boundary conditions
- Analysis of a multi-species Cahn-Hilliard-Keller-Segel tumor growth model with chemotaxis and angiogenesis
- Optimal control of a phase field tumor growth model with chemotaxis and active transport
- A rigorous approach to the sharp interface limit for phase-field models of tumor growth
- Cahn–Hilliard–Brinkman model for tumor growth with possibly singular potentials
- Nonlocal Cahn-Hilliard-Hele-Shaw systems with singular potential and degenerate mobility
- Viscoelastic Cahn–Hilliard models for tumor growth
- Optimal distributed control of two-dimensional Navier-Stokes-Cahn-Hilliard system with chemotaxis and singular potential
- A multiphase Cahn-Hilliard-Darcy model for tumour growth with necrosis
This page was built for publication: Existence of weak solutions to multiphase Cahn-Hilliard-Darcy and Cahn-Hilliard-Brinkman models for stratified tumor growth with chemotaxis and general source terms
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5037294)
