Mathematical modeling of myosin induced bistability of lamellipodial fragments

DOI10.1007/S00285-016-1008-2MaRDI QIDQ504051zbMATH OpenOpenAlexWikidataFDO

Authors Stefanie Hirsch, Angelika Manhart, Christian Schmeiser

Publication date 25 January 2017

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/1511.08602

zbMATH Keywords

actincytoskeletonmathematical modelmyosin

Mathematics Subject Classification ID

Stability of solutions to ordinary differential equations (34D20) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)

Abstract: For various cell types and for lamellipodial fragments on flat surfaces, externally induced and spontaneous transitions between symmetric nonmoving states and polarized migration have been observed. This behavior is indicative of bistability of the cytoskeleton dynamics. In this work, the Filament Based Lamellipodium Model (FBLM), a two-dimensional, anisotropic, two-phase continuum model for the dynamics of the actin filament network in lamellipodia, is extended by a new description of actin-myosin interaction. For appropriately chosen parameter values, the resulting model has bistable dynamics with stable states showing the qualitative features observed in experiments. This is demonstrated by numerical simulations and by an analysis of a strongly simplified version of the FBLM with rigid filaments and planar lamellipodia at the cell front and rear.

Review text

The article considers a model for the dynamics of lamelliapodial filamens orerating with the system of actin-myosin compartments and their interactions. The principal structure is a net of crossing actin filaments, which are pair-wisely connected by myosin links; in addition, these connection can be created and broken in dependence on the forces acting on them. The model construction takes into account energy contribution of various configurations and results in the system of Euler-Lagrange equations obtained via the variational approach that results in the biologically relevant bistable solution. This construction is illustrated with the numerical simulation able to demonstrate that the modelled cell fragments can remain stationary or be in a moving state.

Recommendations

• Mathematical modelling and numerical simulations of actin dynamics in the eukaryotic cell
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Cites work

• An extended filament based lamellipodium model produces various moving cell shapes in the presence of chemotactic signals
• Derivation of a model for symmetric lamellipodia with instantaneous cross-link turnover
• Mathematics of cell motility: Have we got its number?
• Multiscale Two-Dimensional Modeling of a Motile Simple-Shaped Cell

Cited in

(8)

• Mathematical model of contractile ring-driven cytokinesis in a three-dimensional domain
• Modeling myosin-dependent rearrangement and force generation in an actomyosin network
• Mathematical modelling and numerical simulations of actin dynamics in the eukaryotic cell
• Modeling actin-myosin interaction: beyond the Huxley-Hill framework
• Simulation of lamellipodial fragments
• An extended filament based lamellipodium model produces various moving cell shapes in the presence of chemotactic signals
• Dynamics of a cell motility model near the sharp interface limit
• Protrusion of a virtual model lamellipodium by actin polymerization: A coarse-grained langevin dynamics model

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