Existence of and decay to equilibrium of the filament end density along the leading edge of the lamellipodium

DOI10.1007/S00285-016-1027-ZzbMATH Open1414.35241arXiv1509.07625OpenAlexW2403413845WikidataQ40533195 ScholiaQ40533195MaRDI QIDQ504069FDOQ504069

Authors: Angelika Manhart, Christian Schmeiser 

Publication date: 25 January 2017

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: A model for the dynamics of actin filament ends along the leading edge of the lamellipodium is analyzed. It contains accounts of nucleation by branching, of deactivation by capping, and of lateral flow along the leading edge by polymerization. A nonlinearity arises from a Michaelis-Menten type modeling of the branching process. For branching rates large enough compared to capping rates, the existence and stability of nontrivial steady states is investigated. The main result is exponential convergence to nontrivial steady states, proven by investigating the decay of an appropriate Lyapunov functional.

Full work available at URL: https://arxiv.org/abs/1509.07625

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zbMATH Keywords

Lyapunov functionactinlamellipodium

Mathematics Subject Classification ID

Stability in context of PDEs (35B35) Bifurcations in context of PDEs (35B32) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell biology (92C37) Initial-boundary value problems for systems of nonlinear first-order PDEs (35F61)

Cites Work

• Bifurcation from simple eigenvalues
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• The flatness of lamellipodia explained by the interaction between actin dynamics and membrane deformation
• An extended filament based lamellipodium model produces various moving cell shapes in the presence of chemotactic signals

Cited In (4)

• Mini-workshop: PDE models of motility and invasion in active biosystems. Abstracts from the mini-workshop held October 22--28, 2017
• Stability, convergence, and sensitivity analysis of the FBLM and the corresponding FEM
• Derivation of a model for symmetric lamellipodia with instantaneous cross-link turnover
• An extended filament based lamellipodium model produces various moving cell shapes in the presence of chemotactic signals

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