Polarity-driven laminar pattern formation by lateral-inhibition in 2D and 3D bilayer geometries

DOI10.1093/IMAMAT/HXAC011zbMATH Open1501.92005arXiv2104.12142OpenAlexW4290928935WikidataQ114092356 ScholiaQ114092356MaRDI QIDQ5044836FDOQ5044836

Authors: Joshua W. Moore, Trevor C. Dale, Thomas E. Woolley 

Publication date: 2 November 2022

Published in: IMA Journal of Applied Mathematics (Search for Journal in Brave)

Abstract: Fine-grain patterns produced by juxtacrine signalling, have been studied using static monolayers as cellular domains. Unfortunately, analytical results are restricted to a few cells due to the algebraic complexity of nonlinear dynamical systems. Motivated by concentric patterning of Notch expression observed in the mammary gland, we combine concepts from graph and control theory to represent cellular connectivity. The resulting theoretical framework allows us to exploit the symmetry of multicellular bilayer structures in 2D and 3D, thereby deriving analytical conditions that drive the dynamical system to form laminar patterns consistent with the formulation of cell polarity. Critically, the conditions are independent of the precise dynamical details, thus the framework allows for the utmost generality in understanding the influence of cellular geometry on patterning in lateral-inhibition systems. Applying the analytic conditions to mammary organoids suggests that intense cell signalling polarity is required for the maintenance of stratified cell-types within a static bilayer using a lateral-inhibition mechanism. Furthermore, by employing 2D and 3D cell-based models, we highlight that the cellular polarity conditions derived from static domains have the capacity to generate laminar patterning in dynamic environments. However, they are insufficient for the maintenance of patterning when subjected to substantial morphological perturbations. In agreement with the mathematical implications of strict signalling polarity induced on the cells, we propose an adhesion dependent Notch-Delta biological process which has the potential to initiate bilayer stratification in a developing mammary organoid.

Full work available at URL: https://arxiv.org/abs/2104.12142

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zbMATH Keywords

pattern formationnotchnon-linear systemsbilayer structureslateral-inhibitionmammary organoids

Mathematics Subject Classification ID

Systems biology, networks (92C42) Developmental biology, pattern formation (92C15) Cell biology (92C37)

Cited In (2)

• Boundary propagation of planar cell polarity is robust against cell packing pattern
• Modeling Polarity-Driven Laminar Patterns in Bilayer Tissues with Mixed Signaling Mechanisms

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