Mathematical analysis and dynamic active subspaces for a long term model of HIV
From MaRDI portal
Publication:504667
DOI10.3934/MBE.2017040zbMATH Open1366.92126arXiv1604.04588OpenAlexW2963257046WikidataQ40370056 ScholiaQ40370056MaRDI QIDQ504667FDOQ504667
Authors: Tyson Loudon, Stephen Pankavich 
Publication date: 17 January 2017
Published in: Mathematical Biosciences and Engineering (Search for Journal in Brave)
Abstract: Recently, a long-term model of HIV infection dynamics was developed to describe the entire time course of the disease. It consists of a large system of ODEs with many parameters, and is expensive to simulate. In the current paper, this model is analyzed by determining all infection-free steady states and studying the local stability properties of the unique biologically-relevant equilibrium. Active subspace methods are then used to perform a global sensitivity analysis and study the dependence of an infected individual's T-cell count on the parameter space. Building on these results, a global-in-time approximation of the T-cell count is created by constructing dynamic active subspaces and reduced order models are generated, thereby allowing for inexpensive computation.
Full work available at URL: https://arxiv.org/abs/1604.04588
Recommendations
- On the modeling of long-term HIV-1 infection dynamics
- Mathematical analysis of the global dynamics of a model for HIV infection of CD4\(^{+}\) T cells
- Global properties for a class of latent HIV infection dynamics model with CTL immune response
- An in-depth analysis of the HIV-1/AIDS dynamics by comprehensive mathematical modeling
- Sensitivity analysis of a nonlinear lumped parameter model of HIV infection dynamics
Cites Work
- Title not available (Why is that?)
- A model of primary HIV-1 infection
- HIV-1 infection and low steady state viral loads
- Mathematical Analysis of HIV-1 Dynamics in Vivo
- The effects of latent infection on the dynamics of HIV
- An in-host model of HIV incorporating latent infection and viral mutation
- Mathematical analysis of an in-host model of viral dynamics with spatial heterogeneity
- Using mathematics to understand HIV immune dynamics.
- Stochastic modeling of the dynamics of \(CD4^ +\) \(T\)-cell infection by HIV and some Monte Carlo studies
- Title not available (Why is that?)
- Modeling the three stages in HIV infection
- A mathematical model for the dynamics of HIV-1 during the typical course of infection.
- Towards a long-term model construction for the dynamic simulation of HIV infection
- Immunotherapy of HIV-1 infection
- Active subspaces. Emerging ideas for dimension reduction in parameter studies
- Discovering an active subspace in a single‐diode solar cell model
Cited In (8)
- Three-stage modeling of HIV infection and implications for antiretroviral therapy
- A delayed HIV infection model with the homeostatic proliferation of CD\(4^+\) T cells
- Bistable dynamics and Hopf bifurcation in a refined model of early stage HIV infection
- Data-driven polynomial ridge approximation using variable projection
- Dynamical analysis of a delayed HIV virus dynamic model with cell-to-cell transmission and apoptosis of bystander cells
- On the Deep Active-Subspace Method
- Title not available (Why is that?)
- Global sensitivity analysis of plasma instabilities via active subspaces
This page was built for publication: Mathematical analysis and dynamic active subspaces for a long term model of HIV
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q504667)
