Mathematical analysis and dynamic active subspaces for a long term model of HIV

DOI10.3934/MBE.2017040MaRDI QIDQ504667zbMATHOpenAlexWikidataFDO

Authors Tyson Loudon, Stephen Pankavich

Publication date 17 January 2017

Published in Mathematical Biosciences and Engineering (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1604.04588

zbMATH Keywords

dimension reductionsensitivity analysisstability analysisactive subspacesHIV modeling

Mathematics Subject Classification ID

Medical epidemiology (92C60) Epidemiology (92D30)

Abstract: Recently, a long-term model of HIV infection dynamics was developed to describe the entire time course of the disease. It consists of a large system of ODEs with many parameters, and is expensive to simulate. In the current paper, this model is analyzed by determining all infection-free steady states and studying the local stability properties of the unique biologically-relevant equilibrium. Active subspace methods are then used to perform a global sensitivity analysis and study the dependence of an infected individual's T-cell count on the parameter space. Building on these results, a global-in-time approximation of the T-cell count is created by constructing dynamic active subspaces and reduced order models are generated, thereby allowing for inexpensive computation.

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Cited in

(8)

• Three-stage modeling of HIV infection and implications for antiretroviral therapy
• A delayed HIV infection model with the homeostatic proliferation of CD\(4^+\) T cells
• Global sensitivity analysis of plasma instabilities via active subspaces
• Dynamical analysis of a delayed HIV virus dynamic model with cell-to-cell transmission and apoptosis of bystander cells
• Data-driven polynomial ridge approximation using variable projection
• Bistable dynamics and Hopf bifurcation in a refined model of early stage HIV infection
• On the Deep Active-Subspace Method
• scientific article; zbMATH DE number 7650442 (Why is no real title available?)

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