On a model for phase separation on biological membranes and its relation to the Ohta–Kawasaki equation

DOI10.1017/S0956792519000056MaRDI QIDQ5056705zbMATH OpenOpenAlexWikidataFDO

Authors Helmut Abels, Johannes Kampmann

Publication date 8 December 2022

Published in European Journal of Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1810.06654

zbMATH Keywords

Cahn-Hilliard equationphase separationreaction-diffusion systemsPDEs on surfacesOhta-Kawasaki equationinfinitely large affinity between membrane componentslarge cytosolic diffusion

Mathematics Subject Classification ID

Singular perturbations in context of PDEs (35B25) Cell biology (92C37) Initial-boundary value problems for higher-order parabolic systems (35K52)

Abstract: We provide a detailed mathematical analysis of a model for phase separation on biological membranes which was recently proposed by Garcke, R"atz, R"oger and the second author. The model is an extended Cahn-Hilliard equation which contains additional terms to account for the active transport processes. We prove results on the existence and regularity of solutions, their long-time behaviour, and on the existence of stationary solutions. Moreover, we investigate two different asymptotic regimes. We study the case of large cytosolic diffusion and investigate the effect of an infinitely large affinity between membrane components. The first case leads to the reduction of coupled bulk-surface equations in the model to a system of surface equations with non-local contributions. Subsequently, we recover a variant of the well-known Ohta-Kawasaki equation as the limit for infinitely large affinity between membrane components.

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Cited in

(7)

• Existence of weak solutions for a sharp interface model for phase separation on biological membranes
• On the sharp interface limit of a model for phase separation on biological membranes
• Well-posedness and long-time behavior of a bulk-surface coupled Cahn-Hilliard-diffusion system with singular potential for lipid raft formation
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