Computed origami tomography

DOI10.1137/20M1378247zbMATH Open1496.44002OpenAlexW3033242386MaRDI QIDQ5075841FDOQ5075841

Authors Axel Kittenberger, Leonidas Mindrinos, Otmar Scherzer 

Publication date 12 May 2022

Published in SIAM Review (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2006.03446

zbMATH Keywords

Radon transformreconstructiondata simulationX-ray tomographyopen source softwarecryo-microscopyeducational report

Mathematics Subject Classification ID

Radon transform (44A12) Modeling and interdisciplinarity (aspects of mathematics education) (97M10) Biology, chemistry, medicine (aspects of mathematics education) (97M60)

Abstract: In this paper, we provide assembly instructions for an easy to build experimental setup in order to gain practical experience with tomography. In view of this, this paper can be seen as a complementary work to excellent mathematical textbooks at an undergraduate level concerned with the basic mathematical principles of tomography. Since the setup uses light for tomographic imaging, the investigated objects need to be light transparent, like origami figures. In case the reader wants to experiment with computational tomographic reconstructions without assembling the device, we provide a database of several objects together with their tomographic measurements and a publicly available software. Moreover, recent advances in Cryo-imaging enabled three-dimensional high-resolution visualization of single particles, such as for instance viruses. To exemplify, and experience, single particle Cryo-electron microscopy we provide an advanced assembly, which we use to generate data simulating a Cryo-recording. We also discuss some of the major practical difficulties for reconstructing particles from Cryo-microscopic data.

Recommendations

• Cryogenic electron tomography reconstructions from phaseless data
• Tomography
• Reconstruction of pixel-based and geometric objects by discrete tomography. Simulation and physical experiments
• Local Tomography in Electron Microscopy
• A short introduction to tomographic grain map reconstruction

Cites Work

• Covariance matrix estimation for the cryo-EM heterogeneity problem
• Handbook of Mathematical Methods in Imaging
• Integral geometry and three-dimensional reconstruction of randomly oriented identical particles from their electron microphotos
• Mathematical methods in image reconstruction
• Methods of integral geometry and recovering a function with compact support from its projections in unknown directions
• Non-unique games over compact groups and orientation estimation in cryo-EM
• Special issue on cryo-electron microscopy and inverse problems
• The Mathematics of Medical Imaging
• The Radon transform and medical imaging
• The mathematics of computerized tomography
• Theoretically Exact Filtered Backprojection-Type Inversion Algorithm for Spiral CT

Uses Software

• EMan

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