Coarse-Grained Stochastic Model of Myosin-Driven Vesicles into Dendritic Spines
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Publication:5078331
DOI10.1137/21M1434180zbMATH Open1491.92036arXiv2107.07597MaRDI QIDQ5078331FDOQ5078331
Thomas G. Fai, Youngmin Park, Prashant Singh
Publication date: 23 May 2022
Published in: SIAM Journal on Applied Mathematics (Search for Journal in Brave)
Abstract: We study the dynamics of membrane vesicle motor transport into dendritic spines, which are bulbous intracellular compartments in neurons that play a key role in transmitting signals between neurons. We consider the stochastic analog of the vesicle transport model in [Park and Fai, The Dynamics of Vesicles Driven Into Closed Constrictions by Molecular Motors. Bull. Math. Biol. 82, 141 (2020)]. The stochastic version, which may be considered as an agent-based model, relies mostly on the action of individual myosin motors to produce vesicle motion. To aid in our analysis, we coarse-grain this agent-based model using a master equation combined with a partial differential equation describing the probability of local motor positions. We confirm through convergence studies that the coarse-graining captures the essential features of bistability in velocity (observed in experiments) and waiting-time distributions to switch between steady-state velocities. Interestingly, these results allow us to reformulate the translocation problem in terms of the mean first passage time for a run-and-tumble particle moving on a finite domain with absorbing boundaries at the two ends. We conclude by presenting numerical and analytical calculations of vesicle translocation.
Full work available at URL: https://arxiv.org/abs/2107.07597
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