An approach to use of an adaptive procedure to clinical trials for molecularly heterogenous subject selection at interim

DOI10.1080/03610926.2018.1543770MaRDI QIDQ5085585zbMATH OpenOpenAlexFDO

Authors Feng-shou Ko

Publication date 27 June 2022

Published in Communications in Statistics: Theory and Methods (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1080/03610926.2018.1543770

zbMATH Keywords

clinical trialsheterogeneitygenomic biomarkersample size re-estimationphase III trial

Mathematics Subject Classification ID

Statistics (62-XX)

Cites work

• A sample size adjustment procedure for clinical trials based on conditional power
• Discussion on the issue of sample size determination for a targeted to an untargeted and to a mixed effect model-based clinical trial design
• Evaluate the relative efficiency of a targeted clinical trial design to an untargeted design under the issue of cost

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