Dynamic Programming for Response-Adaptive Dose-Finding Clinical Trials

DOI10.1287/IJOC.2021.1082OpenAlexW3211300254MaRDI QIDQ5086016FDOQ5086016

Authors: Amir Ali Nasrollahzadeh, Amin Khademi 

Publication date: 30 June 2022

Published in: INFORMS Journal on Computing (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1287/ijoc.2021.1082

Recommendations

• Optimized response-adaptive clinical trials. Sequential treatment allocation based on Markov decision problems
• Response-adaptive dose-finding under model uncertainty
• scientific article; zbMATH DE number 1984442
• Adaptive designs for selecting drug combinations based on efficacy-toxicity response
• Optimal sequential designs in phase I studies

zbMATH Keywords

dose-finding studiesadaptive clinical trialsknowledge gradientdynamic learning

Mathematics Subject Classification ID

Operations research, mathematical programming (90-XX)

Cites Work

• DATA AUGMENTATION AND DYNAMIC LINEAR MODELS
• Bayesian forecasting and dynamic models.
• An Introduction to Optimal Designs for Social and Biomedical Research
• Multi-armed bandit models for the optimal design of clinical trials: benefits and challenges
• Optimal designs for dose-finding studies
• The knowledge-gradient policy for correlated normal beliefs
• Response-adaptive designs for clinical trials: simultaneous learning from multiple patients
• Bayesian look ahead one-stage sampling allocations for selection of the best population
• Consistency of sequential Bayesian sampling policies
• A Knowledge-Gradient Policy for Sequential Information Collection
• Title not available (Why is that?)
• Covariate-adjusted response-adaptive randomization for multi-arm clinical trials using a modified forward looking Gittins index rule
• Bayesian learning of dose-response parameters from a cohort under response-guided dosing
• A Bayesian decision theoretic model of sequential experimentation with delayed response
• A Bayesian Approach to Dose-Response Assessment and Synergy and Its Application to In Vitro Dose-Response Studies
• Handbook of methods for designing, monitoring, and analyzing dose-finding trials

Cited In (3)

• Approximate dynamic programming and its applications to the design of Phase I cancer trials
• Switched systems as models for dynamic clinical trials
• Estimating optimal shared-parameter dynamic regimens with application to a multistage depression clinical trial

This page was built for publication: Dynamic Programming for Response-Adaptive Dose-Finding Clinical Trials

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5086016)