Methods and Applications of Sample Size Calculation and Recalculation in Clinical Trials

DOI10.1007/978-3-030-49528-2zbMATH Open1452.62005OpenAlexW3107896488MaRDI QIDQ5115628FDOQ5115628

Authors Meinhard Kieser 

Publication date 17 August 2020

Published in Springer Series in Pharmaceutical Statistics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/978-3-030-49528-2

zbMATH Keywords

clinical trialssample size calculationrecalculation

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sampling theory, sample surveys (62D05) Research exposition (monographs, survey articles) pertaining to statistics (62-02)

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• Adapting sample size calculations to repeated measurements in clinical trials
• Sample size recalculation in multicenter randomized controlled clinical trials based on noncomparative data
• Sample size calculations for designing clinical proteomic profiling studies using mass spectrometry
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• Sample size calculation under nonproportional hazards using average hazard ratios
• Cross-product ratio calculation under different sampling schemes in clinical trials -- case study of the CYP-GUIDES trial
• Blinded sample size recalculation in adaptive enrichment designs

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