False discovery rate control for multiple testing based on discrete p-values
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Publication:5120963
DOI10.1002/BIMJ.201900163zbMATH Open1441.62305arXiv1803.06040OpenAlexW3101912299WikidataQ92770970 ScholiaQ92770970MaRDI QIDQ5120963FDOQ5120963
Authors: Xiongzhi Chen 
Publication date: 16 September 2020
Published in: Biometrical Journal (Search for Journal in Brave)
Abstract: For multiple testing based on p-values with c`{a}dl`{a}g distribution functions, we propose an FDR procedure "BH+" with proven conservativeness. BH+ is at least as powerful as the BH procedure when they are applied to super-uniform p-values. Further, when applied to mid p-values, BH+ is more powerful than it is applied to conventional p-values. An easily verifiable necessary and sufficient condition for this is provided. BH+ is perhaps the first conservative FDR procedure applicable to mid p-values. BH+ is applied to multiple testing based on discrete p-values in a methylation study, an HIV study and a clinical safety study, where it makes considerably more discoveries than the BH procedure.
Full work available at URL: https://arxiv.org/abs/1803.06040
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Cited In (13)
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- On fuzzy familywise error rate and false discovery rate procedures for discrete distributions
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- A non-randomized procedure for large-scale heterogeneous multiple discrete testing based on randomized tests
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- A Modified False Discovery Rate Multiple-Comparisons Procedure for Discrete Data, Applied to Human Immunodeficiency Virus Genetics
- Multiple test functions and adjusted \(p\)-values for test statistics with discrete distributions
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