Flexible designs by adaptive plans of generalized Pocock- and O'Brien-Fleming-type and by self-designing clinical trials

DOI10.1002/BIMJ.200510212MaRDI QIDQ5122837zbMATH OpenOpenAlexWikidataFDO

Authors Joachim Hartung

Publication date 24 September 2020

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/bimj.200510212

zbMATH Keywords

adaptive planningflexible designsgeneralized inverse chi-square method.group sequential clinical trialsO'Brien-Fleming-designPocock-designself-designingweighted inverse normal method

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

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Cited in

(5)

• On the efficiency of adaptive designs for flexible interim decisions in clinical trials
• Are Flexible Designs Sound?
• Statistical Inference for Self‐Designing Clinical Trials with a One‐Sided Hypothesis
• Plan to be Flexible: A Commentary on Adaptive Designs
• Adaptive confidence intervals of desired length and power for normal means

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