Bifurcation analysis of a free boundary model of the atherosclerotic plaque formation associated with the cholesterol ratio
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Abstract: The low-density lipoprotein (LDL)/high-density lipoprotein (HDL)-cholesterol ratio has been shown a high correlation with the cardiovascular risk assessment. Is it possible to quantify the correlation mathematically? In this paper, we develop a bifurcation analysis for a mathematical model of the plaque formation with a free boundary in the early stage of atherosclerosis. This bifurcation analysis, to the ratio of LDL/HDL, is based on the explicit formulation of radially symmetric steady-state solutions. By performing the perturbation analysis to these solutions, we establish the existence of bifurcation branches and derive a theoretical condition that a bifurcation occurs for different modes. Then we also analyze the stability of radially symmetric steady-state solutions and conduct numerical simulations to verify all the theoretical results.
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Cited in
(15)- Transfer of low-density lipoproteins in coronary artery bifurcation lesions with stenosed side branch: numerical study
- On the chameleonic behaviour of cholesterol through a fractal/multifractal model
- Mathematical two-compartment model of human cholesterol transport in application to high blood cholesterol diagnosis and treatment
- Bifurcation analysis of a model for atherosclerotic plaque evolution
- Mathematical models of the relationship between HDL-cholesterol and serum triglyceride: An empirical evaluation
- Optimization of vehicle structural parameters considering stability improvement
- On the first bifurcation point for a free boundary problem modeling a small arterial plaque
- Well-posedness of a free boundary problem of early atherosclerotic plaque formation with reverse cholesterol transport
- Growth model for cholesterol accumulation in the wall of a simplified 3D geometry of the carotid bifurcation
- A free boundary mathematical model of atherosclerosis
- Bifurcation for a free boundary model of an atherosclerotic plaque formation in the presence of reverse cholesterol transport with Holling type III functional response
- Asymptotic stability for a free boundary model of an atherosclerotic plaque formation in the presence of reverse cholesterol transport with Holling type-III functional response
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