Multivariate spline estimation and inference for image-on-scalar regression

DOI10.5705/SS.202019.0188zbMATH Open1478.62126arXiv2106.01431OpenAlexW3172870357MaRDI QIDQ5155196FDOQ5155196

Authors: Shan Yu, Guannan Wang, Li Wang, L. Yang 

Publication date: 6 October 2021

Published in: STATISTICA SINICA (Search for Journal in Brave)

Abstract: Motivated by recent data analyses in biomedical imaging studies, we consider a class of image-on-scalar regression models for imaging responses and scalar predictors. We propose using flexible multivariate splines over triangulations to handle the irregular domain of the objects of interest on the images, as well as other characteristics of images. The proposed estimators of the coefficient functions are proved to be root-n consistent and asymptotically normal under some regularity conditions. We also provide a consistent and computationally efficient estimator of the covariance function. Asymptotic pointwise confidence intervals and data-driven simultaneous confidence corridors for the coefficient functions are constructed. Our method can simultaneously estimate and make inferences on the coefficient functions while incorporating spatial heterogeneity and spatial correlation. A highly efficient and scalable estimation algorithm is developed. Monte Carlo simulation studies are conducted to examine the finite-sample performance of the proposed method, which is then applied to the spatially normalized positron emission tomography data of the Alzheimer's Disease Neuroimaging Initiative.

Full work available at URL: https://arxiv.org/abs/2106.01431

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zbMATH Keywords

image analysistriangulationmultivariate splinescoefficient mapsconfidence corridors

Mathematics Subject Classification ID

Classification and discrimination; cluster analysis (statistical aspects) (62H30) Estimation in multivariate analysis (62H12) Numerical computation using splines (65D07) Image analysis in multivariate analysis (62H35)

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Cited In (6)

• Nonparametric quantile scalar-on-image regression
• Statistical Inference for Functional Time Series: Autocovariance Function
• A spatial Bayesian latent factor model for image‐on‐image regression
• Simultaneous confidence corridors for mean functions in functional data analysis of imaging data
• High-Dimensional Spatial Quantile Function-on-Scalar Regression
• Statistical Inference for Mean Function of Longitudinal Imaging Data over Complicated Domains

Uses Software

• fda (R)
• DistMesh
• BPST
• FDAimage

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