Robust modulation of integrate-and-fire models

DOI10.1162/NECO_A_01065MaRDI QIDQ5157155zbMATH OpenOpenAlexDBLPWikidataFDO

Authors Tomas van Pottelbergh, Guillaume Drion, Rodolphe Sepulchre

Publication date 12 October 2021

Published in Neural Computation (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1709.06824

zbMATH Keywords

multiquadratic integrate-and-fire modelneuromodulation mechanismneuronal populations

Mathematics Subject Classification ID

Neural networks for/in biological studies, artificial life and related topics (92B20) Neural biology (92C20)

Abstract: By controlling the state of neuronal populations, neuromodulators ultimately affect behaviour. A key neuromodulation mechanism is the alteration of neuronal excitability via the modulation of ion channel expression. This type of neuromodulation is normally studied via conductance-based models, but those models are computationally challenging for large-scale network simulations needed in population studies. This paper studies the modulation properties of the Multi-Quadratic Integrate-and-Fire (MQIF) model, a generalisation of the classical Quadratic Integrate-and-Fire (QIF) model. The model is shown to combine the computational economy of integrate-and-fire modelling and the physiological interpretability of conductance-based modelling. It is therefore a good candidate for affordable computational studies of neuromodulation in large networks.

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Cites work

• A Generalized Linear Integrate-and-Fire Neural Model Produces Diverse Spiking Behaviors
• An organizing center in a planar model of neuronal excitability
• Dissection of a model for neuronal parabolic bursting
• Modeling the modulation of neuronal bursting: a singularity theory approach

Cited in

(4)

• Cellular switches orchestrate rhythmic circuits
• Mean field model of acetylcholine mediated dynamics in the thalamocortical system
• Detectable and undetectable input signals for the integrate-and-fire model
• From Biophysical to Integrate-and-Fire Modeling

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