Addendum: Action potential propagation and block in a model of atrial tissue with myocyte-fibroblast coupling

DOI10.1093/IMAMMB/DQAB005MaRDI QIDQ5157576zbMATH OpenOpenAlexWikidataFDO

Authors Peter Mortensen, Hao Gao, Radostin D. Simitev

Publication date 19 October 2021

Published in Mathematical Medicine and Biology: A Journal of the IMA (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2104.07165

zbMATH Keywords

asymptotic approximationelectrophysiologymyocyte-fibroblast couplingrefractoriness

Mathematics Subject Classification ID

Physiology (general) (92C30)

Abstract: The analytical theory of our earlier study (Mortensen et al. (2021), Mathematical Medicine and Biology, 38(1), pp. 106-131) is extended to address the outstanding cases of fibroblast barrier distribution and myocyte strait distribution. In particular, closed-form approximations to the resting membrane potential and to the critical parameter values for propagation are derived for these two non-uniform fibroblast distributions and are in good agreement with numerical estimates.

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(3)

• Excitation-contraction coupling between human atrial myocytes with fibroblasts and stretch activated channel current: a simulation study
• Action potential propagation and block in a model of atrial tissue with myocyte-fibroblast coupling
• Simulations of passive properties and action potential conduction in an idealized bullfrog atrial trabeculum

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