Mathematical modeling of lymphocytes selection in the germinal center
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Abstract: Lymphocyte selection is a fundamental operation of adaptive immunity. In order to produce B-lymphocytes with a desired antigenic profile, a process of mutation-selection occurs in the germinal center, which is part of the lymph nodes. We introduce in this article a simplified mathematical model of this process, taking into account the main mechanisms of division, mutation and selection. This model is written as a non-linear, non-local, inhomogeneous second order partial differential equation, for which we develop a mathematical analysis in the case of piecewise-constant coefficients. We assess, mathematically and numerically, the performance of the biological function by evaluating the duration of this production process as a function of several parameters such as the mutation rate or the selection profile, in various asymptotic regimes.
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(13)- Random walks on binary strings applied to the somatic hypermutation of B-cells
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- The type of seeder cells determines the efficiency of germinal center reactions
- A mathematical model for a T cell fate decision algorithm during immune response
- Multi-type Galton-Watson processes with affinity-dependent selection applied to antibody affinity maturation
- A CONCERTED ACTION OF B CELL SELECTION MECHANISMS
- A model for migratory B cell oscillations from receptor down-regulation induced by external chemokine fields
- Germinal center dynamics during acute and chronic infection
- A branching stochastic evolutionary model of the B-cell repertoire
- Exploration of factors affecting the onset and maturation course of follicular lymphoma through simulations of the germinal center
- Dynamics of one-pass germinal center models: implications for affinity maturation
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