Detection of synergistic combinatorial perturbations by a bifurcation-based approach

DOI10.1142/S0218127421501753MaRDI QIDQ5158772zbMATH OpenOpenAlexFDO

Authors Min Luo, Dasong Huang, Jianfeng Jiao, Rui-Qi Wang

Publication date 26 October 2021

Published in International Journal of Bifurcation and Chaos in Applied Sciences and Engineering (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1142/s0218127421501753

zbMATH Keywords

bifurcation-based approachcombinatorial perturbationsEMT networksynergism

Mathematics Subject Classification ID

Bifurcation problems for finite-dimensional Hamiltonian and Lagrangian systems (37J20) Perturbations of finite-dimensional Hamiltonian systems, normal forms, small divisors, KAM theory, Arnol'd diffusion (37J40) Medical applications (general) (92C50)

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Cites work

• A mathematical model for pancreatic cancer growth and treatments
• Domain control of nonlinear networked systems and applications to complex disease networks
• Elements of applied bifurcation theory.
• Methods for determination and approximation of the domain of attraction in the case of autonomous discrete dynamical systems

Cited in

(3)

• A machine learning framework for predicting synergistic and antagonistic drug combinatorial efficacy
• Identifying critical regulatory interactions in cell fate decision and transition by systematic perturbation analysis
• Combinatorial perturbation analysis of CD4+ T cell regulatory networks based on bifurcation theory

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