Modelling transport and mean age of dense core vesicles in large axonal arbours

DOI10.1098/RSPA.2019.0284MaRDI QIDQ5160750zbMATH OpenOpenAlexWikidataFDO

Authors I. A. Kuznetsov, A. V. Kuznetsov

Publication date 29 October 2021

Published in Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1903.10120, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735487

zbMATH Keywords

mathematical modellingneuronsbiomedical engineeringaxonal transportdense core vesiclesneuropeptide transportage density

Mathematics Subject Classification ID

Neural biology (92C20)

Abstract: A model simulating transport of dense core vesicles (DCVs) in type II axonal terminals of Drosophila motoneurons has been developed. The morphology of type II terminals is characterized by the large number of en passant boutons. The lack of both scaled up DCV transport and scaled down DCV capture in boutons results in a less efficient supply of DCVs to distal boutons. Furthermore, the large number of boutons that DCVs pass as they move anterogradely, until they reach the most distal bouton, may lead to the capture of a majority of DCVs before they turn around in the most distal bouton to move in the retrograde direction. This may lead to a reduced retrograde flux of DCVs and a lack of DCV circulation in type II terminals. The developed model simulates DCV concentrations in boutons, DCV fluxes between the boutons, age density distributions of DCVs, and the mean age of DCVs in various boutons. Unlike published experimental observations, our model predicts DCV circulation in type II terminals after these terminals are filled to saturation. This disagreement is likely because experimentally observed terminals were not at steady-state, but rather were accumulating DCVs for later release. Our estimates show that the number of DCVs in the transiting state is much smaller than that in the resident state. DCVs traveling in the axon, rather than DCVs transiting in the terminal, may provide a reserve of DCVs for replenishing boutons after a release. The techniques for modeling transport of DCVs developed in our paper can be used to model the transport of other organelles in axons.

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Cites work

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Cited in

(8)

• Model of reversible vesicular transport with exclusion
• The transport of organelles in axons
• On the role of vesicle transport in neurite growth: modeling and experiments
• Can an increase in neuropeptide production in the soma lead to DCV circulation in axon terminals with type III en passant boutons?
• Modelling of axonal cargo rerouting in a dendrite
• Effect of vesicle traps on traffic jam formation in fast axonal transport
• Modeling neuropeptide transport in various types of nerve terminals containing en passant boutons
• How old are dense-core vesicles residing in en passantboutons: simulation of the mean age of dense-core vesicles in axonal arbours accounting for resident and transiting vesicle populations

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