Modelling thermo-electro-mechanical effects in orthotropic cardiac tissue
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Publication:5161995
DOI10.4208/CICP.OA-2018-0253zbMATH Open1476.92015arXiv1805.00757MaRDI QIDQ5161995FDOQ5161995
Authors: Ricardo Ruiz-Baier, Alessio Gizzi, Alessandro Loppini, Christian Cherubini, Simonetta Filippi 
Publication date: 1 November 2021
Published in: Communications in Computational Physics (Search for Journal in Brave)
Abstract: In this paper we introduce a new mathematical model for the active contraction of cardiac muscle, featuring different thermo-electric and nonlinear conductivity properties. The passive hyperelastic response of the tissue is described by an orthotropic exponential model, whereas the ionic activity dictates active contraction incorporated through the concept of orthotropic active strain. We use a fully incompressible formulation, and the generated strain modifies directly the conductivity mechanisms in the medium through the pull-back transformation. We also investigate the influence of thermo-electric effects in the onset of multiphysics emergent spatiotemporal dynamics, using nonlinear diffusion. It turns out that these ingredients have a key role in reproducing pathological chaotic dynamics such as ventricular fibrillation during inflammatory events, for instance. The specific structure of the governing equations suggests to cast the problem in mixed-primal form and we write it in terms of Kirchhoff stress, displacements, solid pressure, electric potential, activation generation, and ionic variables. We also propose a new mixed-primal finite element method for its numerical approximation, and we use it to explore the properties of the model and to assess the importance of coupling terms, by means of a few computational experiments in 3D.
Full work available at URL: https://arxiv.org/abs/1805.00757
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Cited In (6)
- Mixed Kirchhoff stress-displacement-pressure formulations for incompressible hyperelasticity
- Physical information neural networks for 2D and 3D nonlinear Biot model and simulation on the pressure of brain
- 3D hybrid cellular automata for cardiac electrophysiology: a concept study
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- Thermodynamically consistent orthotropic activation model capturing ventricular systolic wall thickening in cardiac electromechanics
- In silico model of colon electromechanics for manometry prediction after laser tissue soldering
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