Modelling thermo-electro-mechanical effects in orthotropic cardiac tissue
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Publication:5161995
Abstract: In this paper we introduce a new mathematical model for the active contraction of cardiac muscle, featuring different thermo-electric and nonlinear conductivity properties. The passive hyperelastic response of the tissue is described by an orthotropic exponential model, whereas the ionic activity dictates active contraction incorporated through the concept of orthotropic active strain. We use a fully incompressible formulation, and the generated strain modifies directly the conductivity mechanisms in the medium through the pull-back transformation. We also investigate the influence of thermo-electric effects in the onset of multiphysics emergent spatiotemporal dynamics, using nonlinear diffusion. It turns out that these ingredients have a key role in reproducing pathological chaotic dynamics such as ventricular fibrillation during inflammatory events, for instance. The specific structure of the governing equations suggests to cast the problem in mixed-primal form and we write it in terms of Kirchhoff stress, displacements, solid pressure, electric potential, activation generation, and ionic variables. We also propose a new mixed-primal finite element method for its numerical approximation, and we use it to explore the properties of the model and to assess the importance of coupling terms, by means of a few computational experiments in 3D.
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Cites work
- A note on stress-driven anisotropic diffusion and its role in active deformable media
- A simple introduction to the mixed finite element method. Theory and applications
- An active strain electromechanical model for cardiac tissue
- An orthotropic active-strain model for the myocardium mechanics and its numerical approximation
- Bioelectrical effects of mechanical feedbacks in a strongly coupled cardiac electro-mechanical model
- Computational mechanics of the heart.
- Computational modeling of non-linear diffusion in cardiac electrophysiology: a novel porous-medium approach
- Constitutive modelling of passive myocardium: a structurally based framework for material characterization
- Coupling contraction, excitation, ventricular and coronary blood flow across scale and physics in the heart
- Derivation of the bidomain equations for a beating heart with a general microstructure
- Effects of mechano-electrical feedback on the onset of alternans: A computational study
- Finite element and finite volume-element simulation of pseudo-ECGs and cardiac alternans
- Gmsh: a 3-D finite element mesh generator with built-in pre- and post-processing facilities
- Heat transfer in perfused biological tissue. I: General theory
- Integrated heart -- coupling multiscale and multiphysics models for the simulation of the cardiac function
- Locking-free finite element methods for linear and nonlinear elasticity in 2D and 3D
- Minimal model for human ventricular action potentials in tissue
- Numerical sensitivity analysis of a variational data assimilation procedure for cardiac conductivities
- On spiral waves arising in natural systems
- Primal-mixed formulations for reaction-diffusion systems on deforming domains
- The dynamics of spiral tip adjacent to inhomogeneity in cardiac tissue
- The importance of mechano-electrical feedback and inertia in cardiac electromechanics
- Thermodynamically consistent orthotropic activation model capturing ventricular systolic wall thickening in cardiac electromechanics
- Visco-electro-elastic models of fiber-distributed active tissues
- Vortex dynamics in three-dimensional continuous myocardium with fiber rotation: Filament instability and fibrillation
Cited in
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- Mixed Kirchhoff stress-displacement-pressure formulations for incompressible hyperelasticity
- Thermodynamically consistent orthotropic activation model capturing ventricular systolic wall thickening in cardiac electromechanics
- 3D hybrid cellular automata for cardiac electrophysiology: a concept study
- A stabilized mixed three‐field formulation for stress accurate analysis including the incompressible limit in finite strain solid dynamics
- Physical information neural networks for 2D and 3D nonlinear Biot model and simulation on the pressure of brain
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