A mathematical model of granulopoiesis incorporating the negative feedback dynamics and kinetics of G-CSF/neutrophil binding and internalization

DOI10.1007/s11538-016-0179-8zbMath1361.92022arXiv1512.06896OpenAlexW3103689510WikidataQ50561543 ScholiaQ50561543MaRDI QIDQ518219

Michael C. Mackey, Morgan Craig

Publication date: 28 March 2017

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1512.06896

zbMATH Keywords

mathematical modelingstate-dependent delay differential equationsbound and unbound drug concentrationsG-CSFgranulopoiesisphysiologically constructed pharmacokinetics

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Cell biology (92C37)

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Uses Software

• Matlab

Cites Work

• Unnamed Item
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• The complex effect of granulocyte colony-stimulating factor on human granulopoiesis analyzed by a new physiologically-based mathematical model
• Cost-effective G-CSF therapy strategies for cyclical neutropenia: mathematical modelling based hypotheses
• A mathematical model of hematopoiesis. I: Periodic chronic myelogenous leukemia
• A mathematical model of hematopoiesis. II: Cyclical neutropenia
• G-CSF control of neutrophils dynamics in the blood
• Understanding, treating and avoiding hematological disease: better medicine through mathematics?
• On the Use of the Hill Functions in Mathematical Models of Gene Regulatory Networks
• Control of Oscillations in Hematopoiesis
• Long Period Oscillations in aG₀Model of Hematopoietic Stem Cells
• Multistability in an age-structured model of hematopoiesis: cyclical neutropenia

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