Global and local stability for a non-linear hyperbolic system model for the role of stem cells in physiological homeostasis

DOI10.1007/S40314-014-0213-0MaRDI QIDQ520252zbMATH OpenOpenAlexFDO

Authors Laura Di Bernardo, Donatella Donatelli

Publication date 3 April 2017

Published in Computational and Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1408.5070

zbMATH Keywords

age-dependentGompertzian growth

Mathematics Subject Classification ID

Medical applications (general) (92C50) Stability in context of PDEs (35B35) First-order nonlinear hyperbolic equations (35L60) Hyperbolic conservation laws (35L65) Initial-boundary value problems for second-order hyperbolic systems (35L53)

Abstract: In this paper we propose an existence and uniqueness theory for the solutions of a system of non-linear hyperbolic conservation laws, structured in age and maturity variables, representing a tissue environment. In particular we are interested in the investigation of the role of stem cells in its homeostasis. The main result presented in this paper is the consistence of the stability results arising from the analisys of the model we designed with the experimental observations on which several branches of medicine are currently attempting to trade on their research activity.

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Cites work

• scientific article; zbMATH DE number 3885703 (Why is no real title available?)
• scientific article; zbMATH DE number 3476975 (Why is no real title available?)
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Cited in

(4)

• Stability of control networks in autonomous homeostatic regulation of stem cell lineages
• Well-posedness of a coupled PDE-ODE model of stem cell lineage involving homeostatic regulation
• Stability and Hopf bifurcation in a mathematical model of pluripotent stem cell dynamics
• Principal spectral theory for nonlocal systems and applications to stem cell regeneration models

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