Dynamics and bifurcations in a simple quasispecies model of tumorigenesis
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Publication:520291
DOI10.1007/S40314-015-0234-3zbMATH Open1360.92053arXiv1411.6531OpenAlexW1660909672MaRDI QIDQ520291FDOQ520291
Vanessa Castillo, J. Tomás Lázaro, Josep Sardanyés
Publication date: 3 April 2017
Published in: Computational and Applied Mathematics (Search for Journal in Brave)
Abstract: Cancer is a complex disease and thus is complicated to model. However, simple models that describe the main processes involved in tumoral dynamics, e.g., competition and mutation, can give us clues about cancer behaviour, at least qualitatively, also allowing us to make predictions. Here we analyze a simplified quasispecies mathematical model given by differential equations describing the time behaviour of tumor cells populations with different levels of genomic instability. We find the equilibrium points, also characterizing their stability and bifurcations focusing on replication and mutation rates. We identify a transcritical bifurcation at increasing mutation rates of the tumor cells population. Such a bifurcation involves an scenario with dominance of healthy cells and impairment of tumor populations. Finally, we characterize the transient times for this scenario, showing that a slight increase beyond the critical mutation rate may be enough to have a fast response towards the desired state (i.e., low tumor populations) during directed mutagenic therapies.
Full work available at URL: https://arxiv.org/abs/1411.6531
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- Title not available (Why is that?)
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