A spatial filtering approach to biological patterning

DOI10.1137/18M1216092zbMATH Open1429.92038arXiv1902.04614MaRDI QIDQ5206965FDOQ5206965

Authors: Melinda Liu Perkins, Murat Arcak 

Publication date: 19 December 2019

Published in: SIAM Journal on Applied Dynamical Systems (Search for Journal in Brave)

Abstract: Interactions between neighboring cells are essential for generating or refining patterns in a number of biological systems. We propose a discrete filtering approach to predict how networks of cells modulate spatially varying input signals to produce more complicated or precise output signals. The interconnections between cells determine the set of spatial modes that are amplified or suppressed based on the coupling and internal dynamics of each cell, analogously to the way a traditional digital filter modifies the frequency components of a discrete signal. We apply the framework to two systems in developmental biology: the Notch-Delta interaction that shapes extit{Drosophila} wing veins and the Sox9/Bmp/Wnt network responsible for digit formation in vertebrate limbs. The latter case study demonstrates that Turing-like patterns may occur even in the absence of instabilities. Results also indicate that developmental biological systems may be inherently robust to both correlated and uncorrelated noise sources. Our work shows that a spatial frequency-based interpretation simplifies the process of predicting patterning in living organisms when both environmental influences and intercellular interactions are present.

Full work available at URL: https://arxiv.org/abs/1902.04614

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zbMATH Keywords

pattern formationperturbation analysisdevelopmental biologyprepattern processing

Mathematics Subject Classification ID

Developmental biology, pattern formation (92C15)

Cites Work

• The chemical basis of morphogenesis
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• Pattern Formation and Dynamics in Nonequilibrium Systems
• Distributed control of spatially invariant systems
• The Discrete Cosine Transform
• Pattern Formation by Lateral Inhibition in Large-Scale Networks of Cells
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Cited In (5)

• Resonant filtering of compositional waves in multicellular networks
• Morphometry of spatial patterns
• Spatial pattern formation in biology: I. Dermal wound healing. II. Bacterial patterns
• Dynamics of Notch activity in a model of interacting signaling pathways
• Boundary formation by notch signaling in drosophila multicellular systems: eperimental observations and gene network modeling by genomic object net

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