Power priors based on multiple historical studies for binary outcomes
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Publication:5208196
Abstract: Incorporating historical information into the design and analysis of a new clinical trial has been the subject of much recent discussion. For example, in the context of clinical trials of antibiotics for drug resistant infections, where patients with specific infections can be difficult to recruit, there is often only limited and heterogeneous information available from the historical trials. To make the best use of the combined information at hand, we consider an approach based on the multiple power prior which allows the prior weight of each historical study to be chosen adaptively by empirical Bayes. This choice of weight has advantages in that it varies commensurably with differences in the historical and current data and can choose weights near 1 if the data from the corresponding historical study are similar enough to the data from the current study. Fully Bayesian approaches are also considered. The methods are applied to data from antibiotics trials. An analysis of the operating characteristics in a binomial setting shows that the proposed empirical Bayes adaptive method works well, compared to several alternative approaches, including the meta-analytic prior.
Recommendations
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- Dynamic borrowing through empirical power priors that control type I error
- A Study on the Power Parameter in Power Prior Bayesian Analysis
- Power priors for replication studies
- On efficient posterior inference in normalized power prior Bayesian analysis
- SAM: self-adapting mixture prior to dynamically borrow information from historical data in clinical trials
- A dynamic power prior for Bayesian non-inferiority trials
- Unit information prior for adaptive information borrowing from multiple historical datasets
- The scale transformed power prior for use with historical data from a different outcome model
- Borrowing historical information for non-inferiority trials on Covid-19 vaccines
- A Bayesian basket trial design using local power prior
- Eliciting prior information from clinical trials via calibrated Bayes factor
- Bayesian borrowing with multiple heterogeneous historical studies using order restricted normalized power prior
- Unit information Dirichlet process prior
- Optimal priors for the discounting parameter of the normalized power prior
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