Shape design for stabilizing microparticles in inertial microfluidic flows

DOI10.1017/JFM.2019.1007zbMATH Open1460.76648arXiv1902.05935OpenAlexW3098962021WikidataQ126377824 ScholiaQ126377824MaRDI QIDQ5210705FDOQ5210705

Authors: Aditya Kommajosula, Daniel Stoecklein, Dino di Carlo, Baskar Ganapathysubramanian 

Publication date: 21 January 2020

Published in: Journal of Fluid Mechanics (Search for Journal in Brave)

Abstract: Design of microparticles which stabilize at the centerline of a channel flow when part of a dilute suspension is examined numerically for moderate Reynolds numbers ($10leRele80$). Stability metrics for particles with arbitrary shapes are formulated based on linear-stability theory. Particle shape is parametrized by a compact, Non-Uniform Rational B-Spline (NURBS)-based representation. Shape-design is posed as an optimization problem and solved using adaptive Bayesian optimization. We focus on designing particles for maximal stability at the channel-centerline robust to perturbations. Our results indicate that centerline-focusing particles are families of characteristic "fish"/"bottle"/"dumbbell"-like shapes, exhibiting fore-aft asymmetry. A parametric exploration is then performed to identify stable particle-designs at different k's (particle chord-to-channel width ratio) and Re's ($0.1lekle0.4,10leRele80$). Particles at high-k's and Re's are highly stabilized when compared to those at low-k's and Re's. A comparison of the modified dumbbell designs from the current framework also shows better performance to perturbations in Fluid-Structure Interaction (FSI) when compared to the rod-disk model reported previously (Uspal & Doyle 2014) for low-Re Hele-Shaw flow. We identify basins of attraction around the centerline, which span larger release-angle-ranges and lateral locations (tending to the channel width) for narrower channels, which effectively standardizes the notion of global focusing in such configurations using the current stability-paradigm. The present framework is illustrated for 2D cases and is potentially generalizable to stability in 3D flow-fields. The current formulation is also agnostic to Re and particle/channel geometry which indicates substantial potential for integration with imaging flow-cytometry tools and microfluidic biosensing-assays.

Full work available at URL: https://arxiv.org/abs/1902.05935

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zbMATH Keywords

Navier-Stokes equationscomputational methodsmicrofluidics

Mathematics Subject Classification ID

Navier-Stokes equations for incompressible viscous fluids (76D05) Particle methods and lattice-gas methods (76M28)

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Cited In (1)

• Algorithm 1025: PARyOpt: A Software for P arallel A synchronous R emote Ba y esian Opt imization

Uses Software

• PARyOpt

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