Shape design for stabilizing microparticles in inertial microfluidic flows

DOI10.1017/JFM.2019.1007MaRDI QIDQ5210705zbMATH OpenOpenAlexWikidataFDO

Authors Aditya Kommajosula, Daniel Stoecklein, Dino di Carlo, Baskar Ganapathysubramanian

Publication date 21 January 2020

Published in Journal of Fluid Mechanics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1902.05935

zbMATH Keywords

Navier-Stokes equationscomputational methodsmicrofluidics

Mathematics Subject Classification ID

Navier-Stokes equations for incompressible viscous fluids (76D05) Particle methods and lattice-gas methods (76M28)

Abstract: Design of microparticles which stabilize at the centerline of a channel flow when part of a dilute suspension is examined numerically for moderate Reynolds numbers ($10leRele80$). Stability metrics for particles with arbitrary shapes are formulated based on linear-stability theory. Particle shape is parametrized by a compact, Non-Uniform Rational B-Spline (NURBS)-based representation. Shape-design is posed as an optimization problem and solved using adaptive Bayesian optimization. We focus on designing particles for maximal stability at the channel-centerline robust to perturbations. Our results indicate that centerline-focusing particles are families of characteristic "fish"/"bottle"/"dumbbell"-like shapes, exhibiting fore-aft asymmetry. A parametric exploration is then performed to identify stable particle-designs at different k's (particle chord-to-channel width ratio) and Re's ($0.1lekle0.4,10leRele80$). Particles at high-k's and Re's are highly stabilized when compared to those at low-k's and Re's. A comparison of the modified dumbbell designs from the current framework also shows better performance to perturbations in Fluid-Structure Interaction (FSI) when compared to the rod-disk model reported previously (Uspal & Doyle 2014) for low-Re Hele-Shaw flow. We identify basins of attraction around the centerline, which span larger release-angle-ranges and lateral locations (tending to the channel width) for narrower channels, which effectively standardizes the notion of global focusing in such configurations using the current stability-paradigm. The present framework is illustrated for 2D cases and is potentially generalizable to stability in 3D flow-fields. The current formulation is also agnostic to Re and particle/channel geometry which indicates substantial potential for integration with imaging flow-cytometry tools and microfluidic biosensing-assays.

Recommendations

• Inertial migration of a rigid sphere in three-dimensional Poiseuille flow
• Dynamics of Small Particle Inertial Migration in Curved Square Ducts
• Inertial focusing of finite-size particles in microchannels
• Inertial migration of spherical and oblate particles in straight ducts
• Universal motion of mirror-symmetric microparticles in confined Stokes flow

Cites work

• A combined lattice Boltzmann and immersed boundary approach for predicting the vascular transport of differently shaped particles
• A rigid dumbbell settling under gravity in a periodic flow field
• A single dumbbell falling under gravity in a cellular flow field
• Algorithm 1025: PARyOpt: A Software for P arallel A synchronous R emote Ba y esian Opt imization
• Behaviour of macroscopic rigid spheres in Poiseuille flow Part 1. Determination of local concentration by statistical analysis of particle passages through crossed light beams
• Direct simulation of initial value problems for the motion of solid bodies in a Newtonian fluid Part 1. Sedimentation
• Dynamic simulation of the motion of capsules in pipelines
• Hydromechanics of low-Reynolds-number flow. Part 3. Motion of a spheroidal particle in quadratic flows
• Immersogeometric analysis of moving objects in incompressible flows
• Inertial migration of a rigid sphere in three-dimensional Poiseuille flow
• Isogeometric analysis: CAD, finite elements, NURBS, exact geometry and mesh refinement
• Lateral migration and nonuniform rotation of suspended ellipse in Poiseuille flow
• Migration of a sphere in tube flow
• Rigid ring-shaped particles that align in simple shear flow
• The inertial lift on a spherical particle in a plane Poiseuille flow at large channel Reynolds number
• The lift on a small sphere in a slow shear flow
• The lift on a small sphere in wall-bounded linear shear flows
• The motion of rigid particles in a shear flow at low Reynolds number
• Transverse motion of an elastic sphere in a shear field

Cited in

(1)

• Algorithm 1025: PARyOpt: A Software for P arallel A synchronous R emote Ba y esian Opt imization

Describes a project that uses

Uses Software

• PARyOpt

This page was built for publication: Shape design for stabilizing microparticles in inertial microfluidic flows

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5210705)