Non-parametric cure rate estimation under insufficient follow-up by using extremes

DOI10.1111/RSSB.12334MaRDI QIDQ5213451zbMATH OpenOpenAlexWikidataFDO

Authors Mikael Escobar-Bach, Ingrid Van Keilegom

Publication date 3 February 2020

Published in Journal of the Royal Statistical Society Series B: Statistical Methodology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1804.01528

zbMATH Keywords

extreme value theoryright censoringsurvival analysiscure rate

Mathematics Subject Classification ID

Density estimation (62G07) Censored data models (62N01) Reliability and life testing (62N05) Applications of statistics to biology and medical sciences; meta analysis (62P10) Statistics of extreme values; tail inference (62G32)

Abstract: An important research topic in survival analysis is related to the modeling and estimation of the cure rate, i.e. the proportion of subjects that will never experience the event of interest. However, most estimation methods proposed so far in the literature do not handle the case of insufficient follow-up, that is when the right end point of the support of the censoring time is strictly less than that of the survival time of the susceptible subjects, and consequently these estimators overestimate the cure rate in that case. We fill this gap by proposing a new estimator of the cure rate that makes use of extrapolation techniques from the area of extreme value theory. We establish the asymptotic normality of the proposed estimator, and show how the estimator works for small samples by means of a simulation study. We also illustrate its practical applicability through the analysis of data on the survival of breast cancer patients.

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Cited in

(5)

• A new approach to testing for sufficient follow-up in cure-rate analysis
• Extremes of censored and uncensored lifetimes in survival data
• Nonparametric estimation of conditional cure models for heavy-tailed distributions and under insufficient follow-up
• Testing for sufficient follow-up in censored survival data by using extremes
• Mixture cure model methodology in survival analysis: some recent results for the one-sample case

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