Personalized schedules for surveillance of low-risk prostate cancer patients

DOI10.1111/BIOM.12940MaRDI QIDQ5214458zbMATH OpenOpenAlexWikidataFDO

Authors Anirudh Tomer, Daan Nieboer, Monique J. Roobol, Ewout W. Steyerberg, Dimitris Rizopoulos

Publication date 7 February 2020

Published in Biometrics (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/1711.00285

zbMATH Keywords

active surveillancebiopsyjoint modelspersonalized medicineprostate cancer

Mathematics Subject Classification ID

Time series, auto-correlation, regression, etc. in statistics (GARCH) (62M10) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: Low risk prostate cancer patients enrolled in active surveillance (AS) programs commonly undergo biopsies on a frequent basis for examination of cancer progression. AS programs employ a fixed schedule of biopsies for all patients. Such fixed and frequent schedules, may schedule unnecessary biopsies for the patients. Since biopsies have an associated risk of complications, patients do not always comply with the schedule, which increases the risk of delayed detection of cancer progression. Motivated by the world's largest AS program, Prostate Cancer Research International Active Surveillance (PRIAS), in this paper we present personalized schedules for biopsies to counter these problems. Using joint models for time to event and longitudinal data, our methods combine information from historical prostate-specific antigen (PSA) levels and repeat biopsy results of a patient, to schedule the next biopsy. We also present methods to compare personalized schedules with existing biopsy schedules.

Recommendations

• A stochastic approach to risk management for prostate cancer patients on active surveillance
• Real-time individual predictions of prostate cancer recurrence using joint models
• Estimating and comparing cancer progression risks under varying surveillance protocols
• Tailored optimal posttreatment surveillance for cancer recurrence
• Hybrid optimal scheduling for intermittent androgen suppression of prostate cancer

Cited in

(9)

• A stochastic approach to risk management for prostate cancer patients on active surveillance
• scientific article; zbMATH DE number 2043698 (Why is no real title available?)
• Life history analysis with multistate models: A review and some current issues
• Tailored optimal posttreatment surveillance for cancer recurrence
• Shared decision making of burdensome surveillance tests using personalized schedules and their burden and benefit
• Backward joint model and dynamic prediction of survival with multivariate longitudinal data
• Estimating optimally tailored active surveillance strategy under interval censoring
• Personalized biopsy schedules using an interval-censored cause-specific joint model
• A Bayesian joint modeling for misclassified interval-censoring and competing risks

This page was built for publication: Personalized schedules for surveillance of low-risk prostate cancer patients

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5214458)