A Bayesian joint dispersion model with flexible links

DOI10.1007/978-3-319-54084-9_5MaRDI QIDQ5267854zbMATH OpenOpenAlexWikidataFDO

Authors Rui Paulo Martins

Publication date 13 June 2017

Published in Springer Proceedings in Mathematics & Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1604.08853, http://hdl.handle.net/10400.26/17918

zbMATH Keywords

repeated measurementstime-to-eventpenalized splinestime-dependent coefficientsvariance model

Mathematics Subject Classification ID

Bayesian inference (62F15) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: The objective is to model longitudinal and survival data jointly taking into account the dependence between the two responses in a real HIV/AIDS dataset using a shared parameter approach inside a Bayesian framework. We propose a linear mixed effects dispersion model to adjust the CD4 longitudinal biomarker data with a between-individual heterogeneity in the mean and variance. In doing so we are relaxing the usual assumption of a common variance for the longitudinal residuals. A hazard regression model is considered in addition to model the time since HIV/AIDS diagnostic until failure, being the coefficients, accounting for the linking between the longitudinal and survival processes, time-varying. This flexibility is specified using Penalized Splines and allows the relationship to vary in time. Because heteroscedasticity may be related with the survival, the standard deviation is considered as a covariate in the hazard model, thus enabling to study the effect of the CD4 counts' stability on the survival. The proposed framework outperforms the most used joint models, highlighting the importance in correctly taking account the individual heterogeneity for the measurement errors variance and the evolution of the disease over time in bringing new insights to better understand this biomarker-survival relation.

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Cites work

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Cited in

(4)

• Joint analysis of longitudinal and survival AIDS data with a spatial fraction of long-term survivors: a Bayesian approach
• Longitudinal Poisson modeling: an application for CD4 counting in HIV-infected patients
• Improving teeth aesthetics using a spatially shared-parameters model for independent regular lattices
• Flexible link functions in a joint hierarchical Gaussian process model

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