Design of clinical trials involving multiple hypothesis tests with a common control

DOI10.1002/BIMJ.201500230MaRDI QIDQ5280179zbMATH OpenOpenAlexWikidataFDO

Authors I. Manjula Schou, Ian C. Marschner

Publication date 20 July 2017

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/bimj.201500230

zbMATH Keywords

complete powerDunnett adjustmentminimal powermultiple testingoptimal designweighted optimality

Mathematics Subject Classification ID

Paired and multiple comparisons; multiple testing (62J15) Optimal statistical designs (62K05) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

• Optimal designs for multiple treatments with unequal variances
• Optimal Multiple Testing and Design in Clinical Trials
• On optimal designs for clinical trials: an updated review
• Optimal designs for testing the efficacy of heterogeneous experimental groups
• Implementing optimal allocation in clinical trials with multiple endpoints

Cites work

• A Multiple Comparison Procedure for Comparing Several Treatments with a Control
• scientific article; zbMATH DE number 4088796 (Why is no real title available?)
• Implementing Optimal Allocation in Sequential Binary Response Experiments
• Optimal designs for comparing test treatments with controls. With comments and a rejoinder by the authors
• Weighted Optimality in Designed Experimentation

Cited in

(12)

• Optimizing parameters in clinical trials with a randomized start or withdrawal design
• Optimal design for \(p\)-value consistent step-up procedures for multiple comparisons with a control in direction-mixed families
• Optimal designs for testing the efficacy of heterogeneous experimental groups
• On optimal designs for clinical trials: an updated review
• Optimal designs for multiple treatments with unequal variances
• A comparison of allocation strategies for optimising clinical trial designs under variance heterogeneity
• Optimal designs for evaluating a series of treatments
• scientific article; zbMATH DE number 800305 (Why is no real title available?)
• Optimal Multiple Testing and Design in Clinical Trials
• Optimal group sizes for testing group mean differences using the Bayes factor
• Implementing optimal allocation in clinical trials with multiple endpoints
• Hypothesis designs for three-hypothesis test problems

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Uses Software

• MCPMod

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