Bayesian variable selection for post-analytic interrogation of susceptibility loci

DOI10.1111/BIOM.12620MaRDI QIDQ5283318zbMATH OpenOpenAlexWikidataFDO

Authors Siying Chen, Sara Nunez, Muredach P. Reilly, Andrea S. Foulkes

Publication date 21 July 2017

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1111/biom.12620

zbMATH Keywords

spike and slab priorgenome-wide association studies (GWAS)Bayesian variable selection (BVS)long non-coding RNAs (lncRNAs)protein coding gene-level testingregulatory elements

Mathematics Subject Classification ID

Bayesian inference (62F15) Applications of statistics to biology and medical sciences; meta analysis (62P10) Protein sequences, DNA sequences (92D20)

Recommendations

• Bayesian variable selection regression for genome-wide association studies and other large-scale problems
• A Bayesian graphical model for genome-wide association studies (GWAS)
• Scalable variational inference for Bayesian variable selection in regression, and its accuracy in genetic association studies
• Bayesian large-scale multiple regression with summary statistics from genome-wide association studies
• Bayesian group Lasso for nonparametric varying-coefficient models with application to functional genome-wide association studies

Cites work

• Bayesian group Lasso for nonparametric varying-coefficient models with application to functional genome-wide association studies
• Bayesian variable selection in structured high-dimensional covariate spaces with applications in genomics
• Negotiating multicollinearity with spike-and-slab priors

Cited in

(2)

• Variable selection in Bayesian generalized linear‐mixed models: An illustration using candidate gene case‐control association studies
• Multiple loci mapping via model-free variable selection

Describes a project that uses

Uses Software

• R

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