On the combination of c- and D-optimal designs: general approaches and applications in dose-response studies

DOI10.1111/BIOM.12545MaRDI QIDQ5347419zbMATH OpenOpenAlexWikidataFDO

Authors Tim Holland-Letz

Publication date 23 May 2017

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1111/biom.12545

zbMATH Keywords

\(c\)-optimal design\(D\)-optimal designdose-response studiesmultiplicative algorithmsnonlinear regressiontoxicology

Mathematics Subject Classification ID

Optimal statistical designs (62K05) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

• Locally optimal designs for some dose-response models with continuous endpoints
• Optimal designs for estimating critical effective dose under model uncertainty in a dose response study
• Optimal experimental designs for estimating the drug combination index in toxicology
• D-optimal designs for mixed discrete and continuous outcomes analyzed using nonlinear models
• Optimal designs for discriminating between dose-response models in toxicology studies

Cites work

• Adaptive Dc-optimal designs for dose finding based on a continuous efficacy endpoint
• Adaptive designs for dose-finding based on efficacy-toxicity response
• Efficient algorithms for optimal designs with correlated observations in pharmacokinetics and dose-finding studies
• General equivalence theory for optimum designs (approximate theory)
• scientific article; zbMATH DE number 3945143 (Why is no real title available?)
• scientific article; zbMATH DE number 1398490 (Why is no real title available?)
• Locally Optimal Designs for Estimating Parameters
• Monotonic convergence of a general algorithm for computing optimal designs
• On the regularization of singular c-optimal designs
• Optimal Bayesian design applied to logistic regression experiments
• Optimal design for nonlinear response models
• Optimal Design of Experiments
• Optimum experimental designs, with SAS

Cited in

(6)

• Optimal experimental designs for estimating the drug combination index in toxicology
• Optimal designs for dose response curves with common parameters
• D-optimal designs for mixed discrete and continuous outcomes analyzed using nonlinear models
• Blends of statistical designs for dose-response studies¹
• The design heatmap: a simple visualization of D-optimality design problems
• Optimal designs for response functions with a downturn

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