Optimal distributed control of a diffuse interface model of tumor growth
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Cahn-Hilliard equationdistributed optimal controlfirst-order necessary optimality conditionsreaction-diffusion equationstumor growth
Nonlinear initial, boundary and initial-boundary value problems for nonlinear parabolic equations (35K61) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Existence theories for optimal control problems involving partial differential equations (49J20) Optimality conditions for problems involving partial differential equations (49K20) Medical applications (general) (92C50)
Abstract: In this paper, a distributed optimal control problem is studied for a diffuse interface model of tumor growth which was proposed in [A. Hawkins-Daruud, K.G. van der Zee, J.T. Oden, Numerical simulation of a thermodynamically consistent four-species tumor growth model, Int. J. Numer. Math. Biomed. Engng. 28 (2011), 3-24]. The model consists of a Cahn-Hilliard equation for the tumor cell fraction coupled to a reaction-diffusion equation for a variable representing the nutrient-rich extracellular water volume fraction. The distributed control monitors as a right-hand side the reaction-diffusion equation and can be interpreted as a nutrient supply or a medication, while the cost function, which is of standard tracking type, is meant to keep the tumor cell fraction under control during the evolution. We show that the control-to-state operator is Frechet differentiable between appropriate Banach spaces and derive the first-order necessary optimality conditions in terms of a variational inequality involving the adjoint state variables.
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