Abstract: We give cell-probe bounds for the computation of edit distance, Hamming distance, convolution and longest common subsequence in a stream. In this model, a fixed string of symbols is given and one -bit symbol arrives at a time in a stream. After each symbol arrives, the distance between the fixed string and a suffix of most recent symbols of the stream is reported. The cell-probe model is perhaps the strongest model of computation for showing data structure lower bounds, subsuming in particular the popular word-RAM model. * We first give an lower bound for the time to give each output for both online Hamming distance and convolution, where is the word size. This bound relies on a new encoding scheme and for the first time holds even when is as small as a single bit. * We then consider the online edit distance and longest common subsequence problems in the bit-probe model () with a constant sized input alphabet. We give a lower bound of which applies for both problems. This second set of results relies both on our new encoding scheme as well as a carefully constructed hard distribution. * Finally, for the online edit distance problem we show that there is an upper bound in the cell-probe model. This bound gives a contrast to our new lower bound and also establishes an exponential gap between the known cell-probe and RAM model complexities.