Semiparametric relative-risk regression for infectious disease transmission data

DOI10.1080/01621459.2014.896807MaRDI QIDQ5367366zbMATH OpenOpenAlexWikidataFDO

Authors Eben Kenah

Publication date 13 October 2017

Published in Journal of the American Statistical Association (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1210.4630, http://europepmc.org/articles/pmc4489164

zbMATH Keywords

EM algorithmsurvival analysisepidemiologychain-binomial modelsemiparametric relative-risk regression

Mathematics Subject Classification ID

Nonparametric regression and quantile regression (62G08) Reliability and life testing (62N05) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: This paper introduces semiparametric relative-risk regression models for infectious disease data based on contact intervals, where the contact interval from person i to person j is the time between the onset of infectiousness in i and infectious contact from i to j. The hazard of infectious contact from i to j is lambda_0( au)r(�eta_0^T X_{ij}), where lambda_0( au) is an unspecified baseline hazard function, r is a relative risk function, �eta_0 is an unknown covariate vector, and X_{ij} is a covariate vector. When who-infects-whom is observed, the Cox partial likelihood is a profile likelihood for �eta maximized over all possible lambda_0( au). When who-infects-whom is not observed, we use an EM algorithm to maximize the profile likelihood for �eta integrated over all possible combinations of who-infected-whom. This extends the most important class of regression models in survival analysis to infectious disease epidemiology.

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Cited in

(4)

• A Model to Estimate Risk of Infection with Human Herpesvirus 8 Associated with Transfusion from Cross‐Sectional Data
• Models for the Statistical Analysis of Infectious Disease Data
• Incorporating infectious duration‐dependent transmission into Bayesian epidemic models
• Randomization for the susceptibility effect of an infectious disease intervention

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