Optimal screening and discovery of sparse signals with applications to multistage high throughput studies

DOI10.1111/RSSB.12171MaRDI QIDQ5378161zbMATH OpenOpenAlexFDO

Authors Wenguang Sun, T. Tony Cai

Publication date 12 June 2019

Published in Journal of the Royal Statistical Society Series B: Statistical Methodology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1111/rssb.12171

zbMATH Keywords

data screeningdiscovery boundaryfalse discovery ratefalse negative ratehigh throughput screeningmultistage adaptive testingphase transitionscreening boundary

Mathematics Subject Classification ID

Compound decision problems in statistical decision theory (62C25) Nonparametric hypothesis testing (62G10) Paired and multiple comparisons; multiple testing (62J15) Sequential statistical analysis (62L10) Signal theory (characterization, reconstruction, filtering, etc.) (94A12) Detection theory in information and communication theory (94A13)

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Cited in

(15)

• Feature screening in large scale cluster analysis
• Search for sparse active inputs: a review
• Adaptive sparse estimation with side information
• Efficient signal inclusion with genomic applications
• Hierarchical recognition of sparse patterns in large-scale simultaneous inference
• Optimal Transitions for Targeted Protein Quantification: Best Conditioned Submatrix Selection
• Estimating the proportion of signal variables under arbitrary covariance dependence
• Optimal design for high-throughput screening via false discovery rate control
• False discovery rate control for lesion-symptom mapping with heterogeneous data via weighted p-values
• Directional false discovery rate control in large-scale multiple comparisons
• Spatially adaptive variable screening in presurgical functional magnetic resonance imaging data analysis
• Optimal control of directional false discovery rates in large-scale testing
• Unified screening for potential elevated adverse event risk and other associations
• Sparse recovery with multiple data streams: an adaptive sequential testing approach
• Large-scale multiple testing: fundamental limits of false discovery rate control and compound oracle

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