Optimal screening and discovery of sparse signals with applications to multistage high throughput studies

DOI10.1111/RSSB.12171MaRDI QIDQ5378161zbMATH OpenOpenAlexFDO

Authors Wenguang Sun, T. Tony Cai

Publication date 12 June 2019

Published in Journal of the Royal Statistical Society Series B: Statistical Methodology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1111/rssb.12171

zbMATH Keywords

false discovery ratephase transitionhigh throughput screeningfalse negative ratedata screeningdiscovery boundarymultistage adaptive testingscreening boundary

Mathematics Subject Classification ID

Nonparametric hypothesis testing (62G10) Sequential statistical analysis (62L10) Signal theory (characterization, reconstruction, filtering, etc.) (94A12) Paired and multiple comparisons; multiple testing (62J15) Detection theory in information and communication theory (94A13) Compound decision problems in statistical decision theory (62C25)

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Cited in

(15)

• Optimal control of directional false discovery rates in large-scale testing
• Unified screening for potential elevated adverse event risk and other associations
• Sparse recovery with multiple data streams: an adaptive sequential testing approach
• Search for sparse active inputs: a review
• Large-scale multiple testing: fundamental limits of false discovery rate control and compound oracle
• Efficient signal inclusion with genomic applications
• Optimal design for high-throughput screening via false discovery rate control
• Optimal Transitions for Targeted Protein Quantification: Best Conditioned Submatrix Selection
• False discovery rate control for lesion-symptom mapping with heterogeneous data via weighted p-values
• Estimating the proportion of signal variables under arbitrary covariance dependence
• Hierarchical recognition of sparse patterns in large-scale simultaneous inference
• Spatially adaptive variable screening in presurgical functional magnetic resonance imaging data analysis
• Directional false discovery rate control in large-scale multiple comparisons
• Adaptive sparse estimation with side information
• Feature screening in large scale cluster analysis

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