On the spike train variability characterized by variance-to-mean power relationship

DOI10.1162/NECO_A_00748MaRDI QIDQ5380290zbMATH OpenWikidataFDO

Authors Shinsuke Koyama

Publication date 4 June 2019

Published in Neural Computation (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1409.7137

zbMATH Keywords

spike train variabilityvariance-to-mean power relationship

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Neural biology (92C20)

Abstract: We propose a statistical method for modeling the non-Poisson variability of spike trains observed in a wide range of brain regions. Central to our approach is the assumption that the variance and the mean of interspike intervals are related by a power function characterized by two parameters: the scale factor and exponent. It is shown that this single assumption allows the variability of spike trains to have an arbitrary scale and various dependencies on the firing rate in the spike count statistics, as well as in the interval statistics, depending on the two parameters of the power function. We also propose a statistical model for spike trains that exhibits the variance-to-mean power relationship, and based on this a maximum likelihood method is developed for inferring the parameters from rate-modulated spike trains. The proposed method is illustrated on simulated and experimental spike trains.

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Cited in

(7)

• A simple model for low variability in neural spike trains
• Firing Variability Is Higher than Deduced from the Empirical Coefficient of Variation
• Statistical inference on spontaneous neuronal discharge patterns
• Ergodicity and parameter estimates in auditory neural circuits
• Bayesian Estimation of Stimulus Responses in Poisson Spike Trains
• Fluctuation scaling in neural spike trains
• Dethroning the Fano factor: a flexible, model-based approach to partitioning neural variability

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