On the spike train variability characterized by variance-to-mean power relationship

DOI10.1162/NECO_A_00748zbMATH Open1414.92101arXiv1409.7137WikidataQ39006943 ScholiaQ39006943MaRDI QIDQ5380290FDOQ5380290

Authors: Shinsuke Koyama 

Publication date: 4 June 2019

Published in: Neural Computation (Search for Journal in Brave)

Abstract: We propose a statistical method for modeling the non-Poisson variability of spike trains observed in a wide range of brain regions. Central to our approach is the assumption that the variance and the mean of interspike intervals are related by a power function characterized by two parameters: the scale factor and exponent. It is shown that this single assumption allows the variability of spike trains to have an arbitrary scale and various dependencies on the firing rate in the spike count statistics, as well as in the interval statistics, depending on the two parameters of the power function. We also propose a statistical model for spike trains that exhibits the variance-to-mean power relationship, and based on this a maximum likelihood method is developed for inferring the parameters from rate-modulated spike trains. The proposed method is illustrated on simulated and experimental spike trains.

Full work available at URL: https://arxiv.org/abs/1409.7137

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zbMATH Keywords

spike train variabilityvariance-to-mean power relationship

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Neural biology (92C20)

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Cited In (7)

• Statistical inference on spontaneous neuronal discharge patterns
• Firing Variability Is Higher than Deduced from the Empirical Coefficient of Variation
• Fluctuation scaling in neural spike trains
• Ergodicity and parameter estimates in auditory neural circuits
• A simple model for low variability in neural spike trains
• Dethroning the Fano factor: a flexible, model-based approach to partitioning neural variability
• Bayesian Estimation of Stimulus Responses in Poisson Spike Trains

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