Microdomain [Ca^2+] fluctuations alter temporal dynamics in models of Ca^2+-dependent signaling cascades and synaptic vesicle release

DOI10.1162/NECO_A_00811MaRDI QIDQ5380401zbMATH OpenOpenAlexDBLPWikidataFDO

Authors Seth H. Weinberg

Publication date 4 June 2019

Published in Neural Computation (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1162/neco_a_00811

zbMATH Keywords

signaling cascadesneuronal spikingmicrodomain [Ca\(^{2+}\) fluctuations]synaptic vesicle release

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Neural biology (92C20)

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Cites work

• A Review on Phase-type Distributions and their Use in Risk Theory
• Adaptive simulation of hybrid stochastic and deterministic models for biochemical systems
• Adaptive space and time numerical simulation of reaction-diffusion models for intracellular calcium dynamics
• An Introduction to Queueing Theory and Matrix-Analytic Methods
• An introduction to systems biology. Design principles of biological circuits.
• Discrete-state stochastic models of calcium-regulated calcium influx and subspace dynamics are not well-approximated by ODEs that neglect concentration fluctuations
• Modeling and Simulating Chemical Reactions
• Modeling intracellular calcium: diffusion, dynamics, and domains
• Post-transcriptional regulation in the nucleus and cytoplasm: study of mean time to threshold (MTT) and narrow escape problem

Cited in

(3)

• \(\mathrm{Ca}^{2+}\)-activation kinetics modulate successive puff/spark amplitude, duration and inter-event-interval correlations in a Langevin model of stochastic \(\mathrm{Ca}^{2+}\) release
• Stochastic amplification of calcium-activated potassium currents in Ca\(^{2+}\) microdomains
• The magnitude and significance of \(\text{Ca}^{2+}\) domains for release of neurotransmitter

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